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Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case–control studies in European countries

Abstract

Background: Coffee consumption has been associated with an excess bladder cancer risk, but results from epidemiological studies are inconsistent. This association has been long debated, in part due to the potential confounding by smoking. We examined the risk associated with coffee consumption in nonsmokers in a pooled analysis of ten European bladder cancer case–control studies.

Methods: The pooled data set comprises 564 cases and 2929 hospital or population controls who had never smoked. They were enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy and Spain. Information on coffee consumption and occupation was re-coded following standard criteria. Unconditional logistic regression was applied adjusting for age, study center, occupation and gender.

Results: Seventy-nine percent of the study population reported having drunk coffee, and 2.4% were heavy drinkers, reporting having drunk on average ten or more cups per day. There was no excess risk in ever coffee drinkers (OR = 1.0, 95% CI 0.8–1.3) compared to never drinkers. The risk did not increase monotonically with dose but a statistically significant excess risk was seen for subjects having drunk ten or more cups per day (OR = 1.8, 95% CI 1.0–3.3). This excess was seen in both men and women. There was no evidence of an association of the risk with duration or type of coffee consumption. The pooled results were not dependent on the findings of any specific study, but they depended on the type of controls with an overall excess risk observed only for studies using hospital controls.

Conclusion: Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer. Although these results cannot be attributed to confounding by smoking, the possibility of bias in control selection cannot be discarded. On the basis of these results, only a very small proportion of cancers of the bladder among nonsmokers could be attributed to coffee drinking.

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References

  1. 1.

    International Agency for Research on Cancer (1991) IARC Monographs of the Evaluation of Carcinogenic Risks to Humans, vol. 51: Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. Lyon: International Agency for Research on Cancer.

  2. 2.

    Viscoli CM, Lachs MS, Horwitz RI (1993) Bladder cancer and co.ee drinking: a summary of case-control research. Lancet 341: 1432–1437.

  3. 3.

    Escolar Pujolar A, González CA, López-Abente G, et al. (1993) Bladder cancer and co.ee consumption in smokers and non-smokers in Spain. Int J Epidemiol 22: 38–44.

  4. 4.

    Vena JE, Freudenheim J, Graham S, et al. (1993) Coffee, cigarette smoking, and bladder cancer in western New York. Ann Epidemiol 3: 586–591.

  5. 5.

    Momas I, Daures JP, Festy B, Bontoux J, Gremy F (1994) Relative importance of risk factors in bladder carcinogenesis: some new results about Mediterranean habits. Cancer Causes Control 5: 326–332.

  6. 6.

    Donato F, Boffetta P, Fazioli R, Aulenti V, Gelatti U, Porru S (1997) Bladder cancer, tobacco smoking, coffee and alcohol drinking in Brescia, northern Italy. Eur J Epidemiol 13: 795–800.

  7. 7.

    World Cancer Research Fund & American Institute for Cancer Research (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research.

  8. 8.

    Cole P (1971) Coffee drinking and cancer of the lower urinary tract. Lancet 1: 445–451.

  9. 9.

    D'Avanzo B, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I (1992) Coffee consumption and bladder cancer risk. Eur J Cancer 28a: 1480–1484.

  10. 10.

    Clavel J, Cordier S (1991) Coffee consumption and bladder cancer risk. Int J Cancer 47: 207–212.

  11. 11.

    Marrett LD, Walter SD, Meigs JW. Coffee drinking and bladder cancer in Connecticut. Am J Epidemiol 117: 113–127.

  12. 12.

    Kogevinas M, Kauppinen T, Boffetta P, et al. (1998) Estimation of the burden of occupational cancer in Europe. In: IMIM, ed. Final Report to the European Commission of a Project Funded by the Programme “Europe Against Cancer” (Contract SOC 96–200742 05F02). Barcelona: IMIM.

  13. 13.

    `t Mannetje A, Kogevinas M, Chang-Claude J, et al. (1999) Occupation and bladder cancer in European women. Cancer Causes Control 10: 209–217.

  14. 14.

    Kunze E, Chang-Claude J, Frentzel-Beyme R (1992) Life style and occupational risk factors for bladder cancer in Germany. Cancer 69: 1776–1790.

  15. 15.

    Pohlabeln H, Jöckel KH, Bolm-Audorff U (1999) Non-occupational risk factors for cancer of the lower urinary tract in Germany. Eur J Epidemiol 15: 411–419.

  16. 16.

    Greiser E, Molzahn M, eds. (1997) Multi-Center Urothelial and Renal Cancer Study [in German: Multizentrische Nieren-und Urothel-Carcinom-Studie]. Bremerhaven: Wirtschaftsverlag NW, Verlag für Neue Wiss (Schriftenreihe der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin: Forschung; Fb 780).

  17. 17.

    Ciccone G, Vineis P (1988) Coffee drinking and bladder coffee. Cancer Lett 41: 45–52.

  18. 18.

    Fortuny J, Serra C, Bonfill X, Kogevinas M, Sunyer J (1999) Social class differences in bladder cancer in Catalonia. Gac Sanit 13: 208–217.

  19. 19.

    Rebelakos A, Trichopoulos D, Tzonou A, Zavitsanos X, Velonakis E, Trichopoulos A (1985) Tobacco smoking, co.ee drinking and occupation as risk factors for bladder cancer in Greece. J Natl Cancer Inst 75: 455–461.

  20. 20.

    Jensen OM, Wahrendorf J, Knudsen JB, Sorensen BL (1986) The Copenhagen case-control study of bladder cancer. II. Effect of coffee and other beverages. Int J Cancer 37: 651–657.

  21. 21.

    Brady AR (1998) Adjusted population attributable fractions from logistic regression. Stata Technical Bulletin 42: 8–12.

  22. 22.

    Mosteller F, Colditz GA (1996) Understanding research synthesis (meta-analysis). Annu Rev Public Health 17: 1–23.

  23. 23.

    Tredaniel J, Boffetta P, Saracci R, Hirsch A (1993) Environmental tobacco smoke and the risk of cancer in adults. Eur J Cancer 29A: 2058–2068.

  24. 24.

    Wilkens LR, Kadir MM, Kolonel LN, Nomura AM, Hankin JH (1996) Risk factors for lower urinary tract cancer: the role of total fluid consumption, nitrites and nitrosamines, and selected foods. Cancer Epidemiol Biomarkers Prev 5: 161–166.

  25. 25.

    Bruemmer B, White E, Vaughan TL, Cheney CL (1997) Fluid intake and the incidence of bladder cancer among middle-aged men and women in a three-county area of western Washington. Nutr Cancer 29: 163–168.

  26. 26.

    Michaud DS, Spiegelman D, Clinton SK, et al. (1999) Fluid intake and the risk of bladder cancer in men. N Engl J Med 340: 1390–1397.

  27. 27.

    Hartge P, Hoover R, West DW, Lyon JL (1983) Coffee drinking and risk of bladder cancer. J Natl Cancer Inst 70: 1021–1026.

  28. 28.

    Wacholder S, Silverman DT, McLaughlin JK, Mandel JS (1992) Selection of controls in case-control studies. II. Types of controls. Am J Epidemiol 135: 1029–1041.

  29. 29.

    MacMahon B, Trichopoulos D (1999) Epidemiology. Principles and Methods. 2nd edn. Boston: Little Brown.

  30. 30.

    Silverman DT, Hoover RN, Swanson GM, Hartge P (1983) The prevalence of co.ee drinking among hospitalized and population-based control groups. JAMA 249: 1877–1880.

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Sala, M., Cordier, S., Chang-Claude, J. et al. Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case–control studies in European countries. Cancer Causes Control 11, 925–931 (2000). https://doi.org/10.1023/A:1026524014954

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  • bladder cancer
  • coffee consumption
  • nonsmokers