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The major histocompatibility complex and the chemosensory signalling of individuality in humans

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Abstract

The chemosensory identity of mice and rats is determined partly by polymorphic genes of the major histocompatibility complex (MHC). In inbred strains of mice, as well as in seminatural populations, MHC‐associated mating preferences selectively influence reproductive success, thus serving to promote heterozygocity in the MHC. In order to determine whether MHC‐associated chemosignals are present in humans, two studies were conducted. In a first study, olfactory identification of MHC‐associated chemosignals was conducted on 12 trained rats' responses to the urine odors of humans. In a second study, MHC‐associated olfactory cues in humans were analyzed by means of gas chromatography. The results indicate that the urine odors of humans are associated with the MHC and demonstrate that the profile of volatile components in the urine odors shows some association with the MHC. Furthermore, results show that a profile of some specific components, as well as a few ubiquitous volatiles, constitutes MHC‐associated odor signals in humans.

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References

  • Beauchamp, G.K., K. Yamazaki, J. Bard & E.A. Boyse, 1988. Preweaning experience in the control of mating preferences by genes in the major histocompatibility complex of the mouse. Behav. Genet. 18: 537-547.

    Article  PubMed  CAS  Google Scholar 

  • Bestmann, H.J., K. Haberkorn, O. Vostrowsky, F. Eggert & R. Ferstl, 1994. Chemical analysis of urinary chemosignals in humans. Adv. Biosci. 93: 529-534.

    Google Scholar 

  • Boland, W., P. Ney, L. Jänicke & G. Gassmann, 1984. Analysis of Volatiles. De Gruyter, Berlin.

    Google Scholar 

  • Boyse, E.A., G.K. Beauchamp, J. Bard & K. Yamazaki, 1991. Behavior and the major histocompatibility complex of the mouse, pp. 831-846 in Psychoneuroimmunology, 2nd edn., edited by R. Ader, D.L. Felten and N. Cohen. Academic Press, San Diego.

    Google Scholar 

  • Boyse, E.A., G.K. Beauchamp, K. Yamazaki, & J. Bard, 1990. Genetic components of kin recognition in mammals. pp. 148- 161 in Kin Recognition, edited by P.G. Hepper, Cambridge University Press, London.

    Google Scholar 

  • Brown, J.L. & A. Eklund, 1994. Kin recognition and the major histocompatibility complex: An integrative review. American Naturalist 143: 435-461.

    Article  Google Scholar 

  • Brown, R.E., P.B. Singh, & B. Roser, 1987. The major histocompatibility complex and the chemosensory recognition of individuality in rats. Physiol. Behav. 40: 65-73.

    Article  PubMed  CAS  Google Scholar 

  • Bruce, H., 1959. An exteroceptive block to pregnancy in the mouse. Nature 184: 105.

    Article  PubMed  CAS  Google Scholar 

  • Bruce, H., 1960. A block to pregnancy in the mouse caused by proximity of strange males. J. Reproduct. Fertility 1: 96-103.

    Article  CAS  Google Scholar 

  • Duncan, H.J., G.K. Beauchamp, & K. Yamazaki, 1992. Assessing odor generalization in the rat: A sensitive technique. Physiol. Behav. 52: 617-620.

    Article  PubMed  CAS  Google Scholar 

  • Eggert, F., C. Höller, D. Luszyk, W. Müller-Ruchholtz & R. Ferstl, 1997. MHC-associated and MHC-independent urinary chemosignals in mice. Physiol. Behav. 61: 957-961.

    Article  PubMed  Google Scholar 

  • Eggert, F., B. Wobst, N. Zavazava, W. Müller-Ruchholtz & R. Ferstl, 1994. Psychobiology of the immune system: Behavioral factors in the maintenance of immunogenetical variability. Psychologische Beiträge. 36: 152-157.

    Google Scholar 

  • Ferstl, R., F. Eggert, E. Westphal, N. Zavazava, & W. Müller-Ruchholtz, 1992. MHC-related odors in humans, pp. 205-211 in Chemical Signals in Vertebrates VI, edited by R.L. Doty and D. Müller-Schwarze. Plenum, New York.

    Google Scholar 

  • Giphart, M.J. & J. D'Amaro, 1983. HLA and reproduction? J. Immunogen. 10: 25-29.

    CAS  Google Scholar 

  • Manning, C.J., E.K. Wakeland & W. K. Potts, 1992. Communal nesting patterns in mice implicate MHC genes in kin recognition. Nature 360: 581-583.

    Article  PubMed  CAS  Google Scholar 

  • McCormick, J.P., B.A. Sommerville, F. Eggert, B. Wobst & D.M. Broom, 1994. Gas chromatography and pattern matching of headspace samples from human sweat. Adv. Biosci. 93: 539-542.

    Google Scholar 

  • Nordlander, C., L. Hammarström, B. Lindblom & C.I.E.E. Smith, 1983. No role of HLA in mate selection. Immunogenetics 18: 429-431.

    Article  PubMed  CAS  Google Scholar 

  • Pollack, M.S., C.J. Wysocki, G.K. Beauchamp, D. Braun, C. Callaway & B. Dupont, 1982. Absence of HLA association or linkage for variations in sensitivity to the odor of androstenone. Immunogenetics 15: 579-589.

    PubMed  CAS  Google Scholar 

  • Porter, R.H., 1991. Human reproduction and the mother-infant relationship: The role of odors, pp. 429-442 in Smell and Taste in Health and Disease, edited by T.V. Getchell, L.M. Bartoshuk, R.L. Doty and J.B. Snow. Raven, New York.

    Google Scholar 

  • Porter, R.H., J.M. Cernoch & F.J. McLaughlin, 1983. Maternal recognition of neonates through olfactory cues. Physiol. Behav. 30: 151-154.

    Article  PubMed  CAS  Google Scholar 

  • Porter, R.H. & J.D. Moore, 1981. Human kin recognition by olfactory cues. Physiol. Behav. 27: 493-495.

    Article  PubMed  CAS  Google Scholar 

  • Potts, W.K., C.J. Manning & E.K. Wakeland, 1991. Mating patterns in seminatural populations of mice influenced by MHC genotype. Nature 352: 619-621.

    Article  PubMed  CAS  Google Scholar 

  • Potts, W.K. & E.K. Wakeland, 1990. Evolution of diversity at the major histocompatibility complex. Trends. Ecol. Evol. 5: 181-187.

    Article  Google Scholar 

  • Potts, W.K. & E.K. Wakeland, 1993. Evolution of MHC genetic diversity: A tale of incest, pestilence and sexual preference. Trends Genet. 9: 181-187.

    Article  Google Scholar 

  • Rosenberg, L.T., D. Cooperman & R. Payne, 1983. HLA and mate selection. Immunogenetics 17: 89-93.

    Article  PubMed  CAS  Google Scholar 

  • Roser, B., R.E. Brown & P.B. Singh, 1991. Excretion of transplantation antigens as signals of genetic individuality, pp. 187-209 in Chemical Senses, Vol. 3: Genetics of Perception and Communications, edited by C.J. Wysocki and M.R. Kare. Marcel Dekker, New York.

    Google Scholar 

  • Schwende, F.J., J.W. Jorgenson & M. Novotny, 1984. Possible chemical basis for histocompatibility-related mating preference in mice. J. Chem. Ecol. 10: 1603-1615.

    Article  CAS  Google Scholar 

  • Sommerville, B.A., B. Wobst, J.P. McCormick, F. Eggert, N. Zavazava & D.M. Broom, 1994. Volatile identity signals in human axillary sweat: The possible influence of MHC class I genes. Adv. Biosci. 93: 535-538.

    Google Scholar 

  • Yamazaki, K., G.K. Beauchamp, J. Bard, E.A. Boyse, & L. Thomas, 1991. Chemosensory identity and immune function in mice, pp. 211-225 in Chemical Senses, Vol. 3: Genetics of Perception and Communications, edited by C.J. Wysocki and M.R. Kare. Marcel Dekker, New York.

    Google Scholar 

  • Yamazaki, K., G.K. Beauchamp, D. Kupniewski, J. Bard, L. Thomas & E.A. Boyse, 1988. Familial imprinting determines H-2 selective mating preferences. Science 240: 1331-1332.

    PubMed  CAS  Google Scholar 

  • Yamazaki, K., G.K. Beauchamp, C.J. Wysocki, J. Bard, L. Thomas & E.A. Boyse, 1983. Recognition of H-2 types in relation to the blocking of pregnancy in mice. Science 221: 186-188.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Psychology, University of Kiel, D‐24098, Kiel, Germany

    Frank Eggert, Dagmar Luszyk & Roman Ferstl

  2. Institute of Organic Chemistry, University of Erlangen‐Nuernberg, D‐, 91054, Erlangen, Germany

    Klaus Haberkorn, Otto Vostrowsky & Hans Jürgen Bestmann

  3. Institute ofImmunology, University of Kiel, D‐, 24098, Kiel, Germany

    Birgit Wobst, Eckhard Westphal & Wolfgang Müller‐ruchholtz

Authors
  1. Frank Eggert
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  2. Dagmar Luszyk
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  3. Klaus Haberkorn
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  4. Birgit Wobst
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  5. Otto Vostrowsky
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  6. Eckhard Westphal
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  7. Hans Jürgen Bestmann
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  8. Wolfgang Müller‐ruchholtz
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  9. Roman Ferstl
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Eggert, F., Luszyk, D., Haberkorn, K. et al. The major histocompatibility complex and the chemosensory signalling of individuality in humans. Genetica 104, 265–273 (1998). https://doi.org/10.1023/A:1026431303879

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  • DOI: https://doi.org/10.1023/A:1026431303879

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