Skip to main content
SpringerLink
Log in

Mesenchymal Bone Marrow Stem Cells More Effectively Stimulate Regeneration of Deep Burn Wounds than Embryonic Fibroblasts

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Regeneration of deep burn wounds after transplantation of allogenic and autogenic fibroblast-like bone marrow mesenchymal stem cells and embryonic fibroblasts on burn surface was studied in 40 Wistar rats. Transplantation of allogenic and autogenic fibroblast-like bone marrow mesenchymal stem cells and transplantation of embryonic fibroblasts decreased cell infiltration of the wound and accelerated the formation of new vessels and granulation tissue in the wound in comparison with the control (burn wounds without cell transplantation). Regeneration processes were most active after transplantation of fibroblast-like bone marrow mesenchymal stem cells, in particular, autogenic cells, which was confirmed by more rapid decrease in burn surface area. Wound healing after transplantation of fibroblast-like bone marrow mesenchymal cells and embryonic fibroblasts was associated with long functioning of transplanted cells (as was shown by staining for β-galactosidase, the cells were transfected with an adenovirus vector carrying the marker gene). It is hypothesized that more rapid regeneration of burn wounds after transplantation of fibroblast-like bone marrow mesenchymal stem cells was due to low differentiation of these cells in comparison with embryonic fibroblasts.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. E. G. Kolokol'chikova, L. I. Budkevich, A. E. Bobrovnikov, et al., Byull. Eksp. Biol. Med., 131, No. 1, 107-111 (2001).

    Google Scholar 

  2. M. F. Rasulov, A. M. Khadzhibaev, and M. D. Urazmetova, Med. Zh. Uzbekistana, No. 5-6, 87-88 (2001).

  3. D. S. Sarkisov, A. A. Alekseev, E. V. Glushchenko, et al., Vestn. Rossiisk. Akad. Med. Nauk, No. 6, 6-11 (1996).

  4. V. I. Shumakov, M. F. Rasulov, M. E. Krasheninnikov, et al., Vestn. Transplantol. Iskusstv. Organov, No. 4, 7-11 (2002).

  5. H. Goto, F. D. Shuler, C. Lamsam, et al., J. Bone Joint Sur. Am., 81, No. 7, 918-925 (1999).

    Google Scholar 

  6. R. Gruber, C. Mayer, W. Schulz, et al., Cytokine, 12, No. 11, 1630-1638 (2000).

    Google Scholar 

  7. M. K. Majumdar, V. Banks, D. P. Peluso, and E. A. Morris, J. Cell. Physiol., 185, No. 1, 98-106 (2000).

    Google Scholar 

  8. M. F. Pittenger, A. M. Mackay, S. C. Beck, et al., Science, 284, 143-147 (1999).

    Google Scholar 

  9. B. Seshi, S. Kumar, and D. Sellers, Blood Cells Mol. Dis., 26, No. 3, 234-246 (2000).

    Google Scholar 

  10. S. Teramoto, H. Ito, and Y. Ouchi, Thromb. Res., 93, No. 1, 35-42 (1999).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Transplantology and Artificial Organs, Ministry of Health of Russian Federation, Moscow

    V. I. Shumakov, N. A. Onishchenko, M. F. Rasulov, M. E. Krasheninnikov & V. A. Zaidenov

Authors
  1. V. I. Shumakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. A. Onishchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. F. Rasulov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. E. Krasheninnikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. A. Zaidenov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. E. Krasheninnikov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shumakov, V.I., Onishchenko, N.A., Rasulov, M.F. et al. Mesenchymal Bone Marrow Stem Cells More Effectively Stimulate Regeneration of Deep Burn Wounds than Embryonic Fibroblasts. Bulletin of Experimental Biology and Medicine 136, 192–195 (2003). https://doi.org/10.1023/A:1026387411627

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026387411627

Search

Navigation