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Unrelated and related cord blood banking and hematopoietic graft engineering

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Abstract

The first successful transplantation of umbilical-cord blood (CB) was performed in 1988 to treat a boy with Fanconi's anemia, using CB from his HLA full-matched sister. A few years later, CB transplantation (CBT) was also performed in an adult recipient, however major obstacles still prevent a wider application of CBT in this age group. The principle limiting-factor is the low numbers of nucleated (NC) and CD34+ cells available for transplantation compared to a typical bone marrow (BM)/peripheral blood (PB) allograft, resulting in a lower engraftment success as well as delayed hematopoietic recovery with its characteristic complications, including infections and transplant related mortality (TRM). Other problems include uncertainty regarding potency and efficacy of graft versus leukemia (GvL)/tumor effects in this kind of transplant, considering the reduced graft versus host disease (GvHD) manifestations and immunologic prematurity. These subjects are reviewed with orientation to technical methods directed to improve CB grafts and graft engineering.

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Authors and Affiliations

  1. Department of Hematology, Israel

    Yossi Cohen

  2. Department of Gynecology, Israel

    Doron Kreiser

  3. Department of Cord Blood Bank, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel

    Margarita Mayorov

  4. Department of Bone Marrow Transplantation, Israel

    Arnon Nagler

  5. Department of Cord Blood Bank, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel

    Arnon Nagler

Authors
  1. Yossi Cohen
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  2. Doron Kreiser
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  3. Margarita Mayorov
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  4. Arnon Nagler
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Correspondence to Arnon Nagler.

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Cohen, Y., Kreiser, D., Mayorov, M. et al. Unrelated and related cord blood banking and hematopoietic graft engineering. Cell Tissue Banking 4, 29–35 (2003). https://doi.org/10.1023/A:1026379514314

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