Skip to main content
Log in

Community-Based Responses to Impending or Actual Cardiac Arrest and Advances in Post-Cardiac Arrest Care

  • Published:
Journal of Interventional Cardiac Electrophysiology Aims and scope Submit manuscript

Abstract

Out-of-hospital cardiac arrest remains a major epidemiologic, clinical, scientific, and public health challenge. Emergency rescue systems (EMS) based in fire departments initially demonstrated encouraging outcomes as new strategies were developed in communities led by people committed to such programs, but the overall impact on survival has been modest. With improvement in automated external defibrillator (AED) technology in recent years, there has been increasing interest in their use by non-conventional responders in recent years. In parallel with the AED strategies, adjunctive strategies and therapies have been developed. These include the demonstration that interventions targeted to reperfusion of the ischemic myocardium, such as thrombolytic therapy given by EMS responders, clarification of the role of intravenous amiodarone for electrophysiologically-resistant cardiac arrest victims, and demonstration of a role for hypothermia in post-cardiac arrest. Thus, the range of pre-hospital and in-hospital strategies for improving cardiac arrest survival continues to broaden. The major lesson learned during the past two decades is that no single strategy can be relied upon to yield a major impact on the mortality from out-of-hospital cardiac arrest. The cumulative effect of multiple strategies, working together toward the same goal, will ultimately provide additive effects on outcomes. Carefully thought out strategic approaches can maximize the effect on total mortality.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Myerburg RJ. Sudden cardiac death: Exploring the limits of our knowledge. J Cardiovasc Electrophysiol 2001;12:369–381.

    Google Scholar 

  2. Myerburg RJ. Scientific gaps in the prediction and prevention of sudden cardiac death. J Cardiovasc Electrophysiol 2002;13:709–723.

    Google Scholar 

  3. Pantridge JF, Adgey AA. Pre-hospital coronary care. The mobile coronary care unit. Am J Cardiol 1969;24:666–673.

    Google Scholar 

  4. Liberthson RR, Nagel EL, Hirschman JC, Nussenfeld SR. Prehospital ventricular fibrillation; Prognosis and followup course. N Engl J Med 1974;291:317–321.

    Google Scholar 

  5. Baum RS, Alvarez H, Cobb LA. Survival after resuscitation from out-of-hospital ventricular fibrillation. Circulation 1974;50:1231–1235.

    Google Scholar 

  6. Cummins RO, Eisenberg MS, Bergner L, Hallstrom A, Hearne T, Murray JA. Automatic external defibrillation: Evaluations of its role in the home and in emergency medical services. Ann Emerg Med 1984;13(9. Pt 2):798–801.

    Google Scholar 

  7. Mirowski M, Reid PR, Winkle RA, Mower MM, Watkins L, Jr, Stinson EB, Griffith LS, Kallman CH, Weisfeldt ML. Mortality in patients with implanted automatic defibrillators. Ann Intern Med 1983;98:585–588.

    Google Scholar 

  8. Thompson RG, Hallstrom AP, Cobb LA. Bystanderinitiated cardiopulmonary resuscitation in the management of ventricular fibrillation. Ann Intern Med 1979;90:737–740.

    Google Scholar 

  9. Eisenberg MS, Copass MK, Hallstrom AP, Blake B, Bergner L, Short FA, Cobb LA. Treatment of out-of-hospital cardiac arrests with rapid defibrillation by emergency medical technicians. N Engl J Med 1980;302:1379–1383.

    Google Scholar 

  10. Cobb LA, Weaver WD, Fahrenbruch CE, Hallstrom AP, Copass MK. Community-based interventions for sudden cardiac death. Impact, limitations, and changes. Circulation 1992;85(Suppl 1):I98–I102.

    Google Scholar 

  11. Cummins RO, Ornato JP, Thies WH, Pepe PE. Improving survival from sudden cardiac arrest: The chain of survival concept. Circulation 1991;83:1832–1847.

    Google Scholar 

  12. Nichol G, Hallstrom AP, Kerber R, Moss AJ, Ornato JP, Palmer D, Riegel B, Smith S, Weisfeldt ML. American Heart Association report on the second public access defibrillation conference, April 17–19, 1997. Circulation 1998;97:1309–1314.

    Google Scholar 

  13. Marenco JP, Wang PJ, Link MS, Homoud MK, Estes NAM, II. Improving survival from sudden cardiac arrest: The role of the automated external defibrillator. JAMA 2001;285:1193–1200.

    Google Scholar 

  14. Becker L, Eisenberg M, Fahrenbruch C, Cobb L. Public locations of cardiac arrest: Implications for public access defibrillation. Circulation 1998;97:2106–2109.

    Google Scholar 

  15. Zipes DP. The neighborhood heart watch program: Save a victim everywhere (SAVE). J Am Coll Cardiol 2001;2004–2005.

  16. White RD, Hankins DG, Bugliosi TF. Seven years' experience with early defibrillation by police and paramedics in an emergency medical services system. Resuscitation 1998;39:145–151.

    Google Scholar 

  17. Mosseso VN Jr, Davis EA, Auble TE, Paris PM, Yealy DM. Use of automated external defibrillators by police officers for treatment of out-of-hospital cardiac arrest. Ann Emerg Med 1998;32:200–207.

    Google Scholar 

  18. Waalewijn RA, de Vos R, Koster RW. Out-of-hospital cardiac arrests in Amsterdam and its surrounding areas: Results from the Amsterdam resuscitation study (ARREST) in 'Utstein' style. Resuscitation 1998;38:157–167.

    Google Scholar 

  19. Groh WJ, Newman MM, Beal PE, Fineberg NS, Zipes DP. Limited response to cardiac arrest by police equipped with automated external defibrillators: Lack of survival bene-fit in suburban and rural Indiana—the police as responder automated defibrillation evaluation (PARADE). Acad Emerg Med 2001;8:324–330.

    Google Scholar 

  20. Mosesso VN, Newman MM, Ornato JP, Paris PM, and the National Center for Early Defibrillation Police AED Issues Forum Panelists, Andersen L, Brinsfield K, Dunnavant GR, Frederick J, Groh WJ, Johnston S, Lerner EB, Murphy G, Myerburg RJ, Rosenberg DG, Savino M, Sayre MR, Sciammarella J, Schoen V, Vargo P, van Alem A, White RD. Law Enforcement Agency Defibrillation (LEAD): Proceedings of the National Center for Early Defibrillation Police AED Issues Forum. Prehospital Emergency Care 2002;6:273–282.

    Google Scholar 

  21. Myerburg RJ, Fenster J, Velez, Rosenberg D, Lai S, Kurlansky P, Newton S, Knox M, Castellanos A. Impact of community-wide police car deployment of automated external defibrillators on out-of-hospital cardiac arrest. Circulation 2002;106:1058–1064.

    Google Scholar 

  22. O'Rourke MF, Donaldson E, Geddes JS. An airline cardiac arrest program. Circulation 1997;96:2849–2853.

    Google Scholar 

  23. Page RL, Joglar JA, Kowal RC, Zagrodzky JD, Nelson LL, Ramaswamy K, Barbera SJ, Hamdan MH, McKenas DK. Use of automated external defibrillators by a U.S. airline. N Engl J Med 2000;343:1210–1216.

    Google Scholar 

  24. Valenzuela TD, Roe DJ, Nichol G, Clark LL, Spaite DW, Hardman RG. Outcomes of rapid defibrillation by security officers after cardiac arrest in casinos. N Engl J Med 2000;343:1206–1209.

    Google Scholar 

  25. Weaver WD, Cerqueira M, Hallstrom AP, Litwin PE, Martin JS, Kudenchuk PJ, Eisenberg M. Prehospitalinitiated vs hospital-initiated thrombolytic therapy. The Myocardial Infarction Triage and Interventional Trial. JAMA 1993;270:1211–1216.

    Google Scholar 

  26. Morrison LJ, Verbeek PR, McDonald AC, Sawadsky BV, Cook DJ. Mortality and prehospital thrombolysis for acute myocardial infarction. A meta-analysis. JAMA 2000;283:2686–2692.

    Google Scholar 

  27. Morrow DA, Antman EM, Sayah A, Schuhwerk KC, Giugliano RP, deLemos JA, Waller M, Cohen SA, Rosenberg DG, Cutler SS, McCabe CH, Walls RM, Braunwald E. Evaluation of the time saved by prehospital initiation of reteplase for ST-elevation myocardial infarction: Results of The Early Retavase-Thrombolysis in Myocardial Infarction (ER-TIMI) 19 trial. J Am Coll Cardiol 2002;40:71–77.

    Google Scholar 

  28. Kudenchuk PJ, Cobb LA, Copass MK, Cummins RO, Doherty AM, Fahrenbruch CE, Hallstrom AP, Murray WA, Olsufka M, Walsh T. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation. N Engl J Med 1999;341:871–878.

    Google Scholar 

  29. Dorian P, Cass D, Schwartz B, Cooper R, Gelaznikas R, Barr A. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N Engl J Med 2002;346:884–890.

    Google Scholar 

  30. The hypothermia after cardiac arrest study group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549–556.

    Google Scholar 

  31. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346:557–563.

    Google Scholar 

  32. Eisenberg MS. Life in the Balance: Emergency Medicine and the Quest to Reverse Sudden Death. New York: Oxford University Press, 1977.

    Google Scholar 

  33. Eisenberg MS, Moore J, Cummins RO, Andresen E, Litwin PE, Hallstrom AP, Hearne T. Use of the automatic external defibrillator in homes of survivors of out-of-hospital ventricular fibrillation. Am J Cardiol 1989;63:443–446.

    Google Scholar 

  34. Myerburg RJ, Conde CA, Sung RJ, Mayorga-Cortes A, Mallon SM, Sheps DS, Appel RA, Castellanos A. Clinical, electrophysiologic, and hemodynamic profile of patients resuscitated from prehospital cardiac arrest. Am J Med 1980;68:568–576.

    Google Scholar 

  35. Stults KR, Brown DD, Schug VL, Bean JA. Prehospital defibrillation performed by emergency medical technicians in rural communities. N Engl J Med 1984;310:219–223.

    Google Scholar 

  36. Lombardi G, Gallagher J, Gennis P. Outcome of out-ofhospital cardiac arrest in New York City: The pre-hospital arrest survival evaluation study. JAMA 1994;271:678–683.

    Google Scholar 

  37. Becker LB, Ostrander MP, Barrett J, Kondos GT. Outcome of CPR in a large metropolitan area—where are the survivors? Ann Emerg Med 1991;20:355–361.

    Google Scholar 

  38. Stiell IG, Wells GA, Field BJ, Spaite DW, De Maio VJ, Ward R, Munkley DP, Lyver MB, Luinstra LG, Campeau T, Maloney J, Dagnone E. Improved out-of-hospital cardiac arrest survival through the inexpensive optimization of an existing defibrillation program: OPALS study phase II. Ontario Prehospital Advanced Life Support. JAMA 1999;281:1175–1181.

    Google Scholar 

  39. Smith SC, Hamburg RS. Automated external defibrillators: Time for federal and state advocacy and broader utilization. Circulation 1998;97:1321–1324.

    Google Scholar 

  40. Capucci A, Aschiere D, Piepoli MF, Bardy GH, Iconomu E, Arvedi M. Tripling survival from sudden cardiac arrest via early defibrillation without traditional education in cardiopulmonary resuscitation. Circulation 2002;106:1065–1070.

    Google Scholar 

  41. Caffrey SL, Willoughby PJ, Pepe PE, Becker LB. Public use of automated external defibrillators. N Engl J Med 2002;347:1242–1247.

    Google Scholar 

  42. de Vreede-Swagemakers JJ, Gorgels AP, Dubois-Arbouw WI, Dalstra J, Daemen MJ, van Ree JW, Stijns RE, Wellens HJ. Circumstances and causes of out-of-hospital cardiac arrest in sudden death survivors. Heart 1998;79:356–361.

    Google Scholar 

  43. Kette F, Sbrojavacca R, Rellini G, Tosolini G, Capasso M, Arcidiacono D, Bernardi G, Frittitta P. Epidemiology and survival rate of out-of-hospital cardiac arrest in northeast Italy: The F.A.C.S. study. Friuli Venezia Giulia Cardiac Arrest Cooperative Study. Resuscitation 1998;36:153–159.

    Google Scholar 

  44. Lien D, Turner M. Recommendations for patients with chronic respiratory disease considering air travel: A statement from the Canadian Thoracic Society. Can Respir J 1998;5:95–100.

    Google Scholar 

  45. DeBehnke DJ, Hilander SJ, Dobler DW, Wickman LL, Swart GL. The hemodynamic and arterial blood gas response to asphyxiation: A canine model of pulseless electrical activity. Resuscitation 1995;30:169–175.

    Google Scholar 

  46. Ochi RP, Goldenberg IF, Almquist A, Pritzer M, Milstein S, Pedersen W, Gobel FL, Benditt DG. Intravenous amiodarone for the rapid treatment of life-threatening ventricular arrhythmias in critically ill patients with coronary artery disease. Am J Cardiol 1989;64:599–603.

    Google Scholar 

  47. American Heart Association. International Guidelines 2000 for CPR and ECC. Circulation 2000;102(Suppl I):I-1–I-370.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert J. Myerburg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Myerburg, R.J., Velez, M., Fenster, J. et al. Community-Based Responses to Impending or Actual Cardiac Arrest and Advances in Post-Cardiac Arrest Care. J Interv Card Electrophysiol 9, 189–202 (2003). https://doi.org/10.1023/A:1026284407435

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026284407435

Navigation