Non-puerperal lactation and/or hyperprolactinemia in humans have been related to psychological variables in a variety of ways: (1) Non-puerperal nursing; (2) Pseudopregnancy; (3) Rapid weight gain; (4) Psychogenic galactorrhea; (5) Acute prolactin responses to psychological stress; (6) High prolactin levels in persons who cope passively in real life stress situations; (7) Paternal deprivation in women with pathological hyperprolactinemia; (8) Clinical onset of prolactinomas following life-events.
Publications on the above subjects are scattered in the literature as curiosities, anecdotal case-reports or unexplained associations, as there is no theoretical frame of reference to accommodate them. We propose that prolactin is a component of a biological, “maternal”, subroutine, adaptive to the care of the young, which promotes accumulation of fat for the extraordinary expenses of pregnancy and lactation, the production of milk and maternal behavior. In an attempt to characterize the stimuli responsible for the activation of the maternal subroutine in the absence of pregnancy we studied the hormonal profiles of female volunteers during three types of sessions under hypnosis: (1) Relaxation-only, control sessions; (2) Sessions in which a fantasy of “nursing” was induced; (3) Sessions of evocations of memories. Prolactin surges were related to the evocation, with rage, of humiliating experiences, but not with the fantasy of nursing. Cortisol surges were related to surprise and shock and were negatively associated with prolactin. In conclusion—Prolactin and cortisol are measurable markers of two different, and alternative, coping strategies to “psychological stress”.
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Sobrinho LG. Neuropsychiatry of prolactin: Causes and effects. Baillière's Clinical Endocrinology and Metabolism 1991;5:119.
Wieschhoff HA. Artificial stimulation of lactation in primitive cultures. Bulletin of the History of Medicine 1940;8:1403.
Scarpa A. Etnomedicina. Milan: Franco Lucisano, 1979:475.
Auerbach KG, Avery JL. Induced lactation. American J Dis Child 1981;135:340.
Corenblum B, Whitaker M. Inhibition of stress-induced hyperprolactinemia. Brit Med J 1977;4:1328.
Zeitner RM, Frank MV, Freeman SMD. Pharmacogenic and psychogenic aspects of galactorrhea: A case report. Am J Psychiatry 1980;137:111.
Cohen LM, Cassem NH, Molitch ME et al. Pseudonursing: A case of galactorrhea. Am J Psychiatr 1979;136:223.
Aruffo RN. Lactation as a denial of separation. Psychoanal Quart 1971;40:100.
Briehl W, Kulka W. Lactation in a virgin. Psychoanal Quart 1935;4:484–511.
Fava GA, Fava M, Kellner R et al. Depression, hostility and anxiety in hyperprolactinemia. Psychoter Pychosom 1981;36:122.
Kellner R, Buckman MT, Fava GA et al. Hyperprolactinemia, distress, and hostility. Am J Psychiatry 1984;141:759.
Jürgensen O, Bardé B. Psychodynamic findings in women with elevated serum prolactin. In: Dennerstein L, De Senarclens M. eds. The Young Woman. Amsterdam: Excerpta Medica, 1983:210.
Reavley S, Fisher AD, Owen D et al. Psychological distress in patients with hyperprolactinemia. Clin Endocrinol 1997; 47:343.
Schwartz TB. Year book of Endocrinology. Year Book Medical Publishers, 1985:61.
Rothchild E. Psychologic aspects of galactorrhea. J Psychosom Obst Gynecol 1985;4:185.
Sobrinho LG, Sá-Melo P, Nunes MCP et al. Sexual dysfunction in hyperprolactinemic women. Effect of bromocriptine. J Psychosomatic Obstetrics and Gynecology 1987;6:43.
Nunes MCP, Sobrinho LG, Calhaz-Jorge C et al. Psychosomatic factors in patients with hyperprolactinemia and/or galactorrhea. Obstetrics & Gynecology 1980;55:591.
Assies J, Vingerhoets AJJM, Poppelaars K. Psychosocial aspects of hyperprolactinemia. Psychoneuroendocrinology 1992;17:673.
Rojas LM, Sthory I, Canales ES et al. Factores psicogénicos en el sindroma de amenorrea-galactorrea. Ginecologia y Obstetricia de México 1981;49:291.
Sobrinho LG, Nunes MCP, Calhaz-Jorge C et al. Hyperprolactinemia in women with paternal deprivation during childhood. Obstetrics & Gynecology 1984;64:465.
Sonino N, Navarrini C, Fallo F et al. A role of stressful life events in the pathogenesis of hyperprolactinemia. The Endocrine Society 85th Annual Meeting 2003 (P1–642).
Ma W, Ikeda H, Yoshimoto T. Clinicopathologic study of 123 cases of prolactin-secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas. Cancer 2002;95:258.
Molitch ME. Disorders of prolactin secretion. Endocrinol Metab Clin North Am 2001;30:585.
Ferreira MF, Sobrinho LG, Pires JS et al. Endocrine and psychological evaluation of women with recent weight gain. Psychoneuroendocrinology 1995;20:53.
Ferreira MF, Sobrinho LG, Santos MA et al. Weight gain, at least in some women, is an expression of a neuroendocrine state characterized by reduced hypothalamic dopaminergic tone. Psychoneuroendocrinology 1998;23:1005.
Sobrinho LG. The psychosomatic interface: Hyperprolactinemia. In: Horseman ND, ed. Prolactin. Boston: Kluwer Academic Press, 2001:100.
Biondi M, Picardi A. Psychological stress and neuroendocrine function in humans: The last two decades of research. Psychoter Psychosom 1999;68:114.
Sobrinho LG, Simões M, Barbosa L et al. Cortisol, prolactin and growth hormone responses to emotions elicited during an hypnoidal state. Psychoneuroendocrinology 2003;28:1.
Reichlin S. Prolactin and growth hormone in stress. In: Chrousos GP, Loriaux DL, Gold PW, eds. Mechanisms of Physical and Emotional Stress. New York: Plenum Press, 1988:353.
Theorell T. Prolactin—A hormone that mirrors passiveness in crisis situations. Integrative Physiological and Behavioral Science 1992;27:32.
Lozoff B, Felt BT, Nelson EC et al. Serum prolactin and behavior in infants. Biol Psychiatry 1995;37:4.
Odendaal JSJ, Meintjes RA. Neurophysiological correlates of affiliative behaviour between humans and dogs. Vet J 2003;165:296.
Falsetti L, Gambera A, Barbetti L et al. Long-term follow-up of functional hypothalamic amenorrhea and prognostic factors. J Clin Endocrinol Metab 2002;87:500.
Illingworth PJ, Jung RT, Howie PW et al. Reduction in postprandial energy expenditure during pregnancy. Brit Med J 1987;294:1573.
Uvnäs-Moberg K. Role of efferent and afferent vagal nerve activity during reproduction: Integrating function of oxytocin on metabolism and behavior. Psychoneuroendocrinology 1994;19:687.
Colao A, Di Sarno A, Cappabianca P et al. Gender differences in the prevalence, clinical features and response to cabergoline in hyperprolactinemia. Europ J Endocrinol 2003;148:325.
Bridges RS, Mann PE. Prolactin-brain interactions in the induction of maternal behavior in rats. Psychoneuroendocrinology 1994;19:611.
Roberts RL, Jenkins KT, Lawler T, Jr et al. Bromocriptine administration lowers serum prolactin and disrupts parental responsiveness in common marmosets (Callithrix j. jacchus). Horm Behav 2001;39:106.
Bernbaum JC, Pereira GR, Watkins JB et al. Nonnutritive sucking during gavage feeding enhances growth and maturation in premature infants. Pediatrics 1983;71:41.
Terkel J. Neuroendocrine processes in the establishment of pregnancy and pseudopregnancy in rats. Psychoneuroendocrinology 1988;13:5.
Bowman LA, Dilley SR, Keverne EB. Suppression of estrogeninduced LH surges by social subordination in talapoin monkeys. Nature 1978;275:56.
Voith VL Functional significance of pseudocyesis. Modern Veterinary Practice 1980;61:75.
Dixon AF, George L. Prolactin and parental behavior in a male New World primate. Nature 1982;299:551.
Ziegler TE, Wegner FH, Snowdon CT. Hormonal responses to parental and non-parental conditions in male cotton-top tamarins, Saguinus oedipus, a NewWorld primate. Horm Behav 1996;30:287.
Reburn CJ, Wynne-Edwards KE. Hormonal changes in males of a naturally biparental and a uniparental mammal. Horm Behav 1999;35:163.
Sandler J, Dare C, Holder A. The patient and the analyst. London: Allen and Unwin, 1973:73.
Sobrinho LG, Almeida-Costa JM. Hyperprolactinemia as a result of immaturity or regression: The concept of maternal subroutine. Psychoter Psychosom 1992;57:128–132.
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Sobrinho, L.G. Prolactin, Psychological Stress and Environment in Humans: Adaptation and Maladaptation. Pituitary 6, 35–39 (2003). https://doi.org/10.1023/A:1026229810876
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