Skip to main content
Log in

Plasma Concentration Profile of Orally Administered Pimobendan and Plasma Brain Natriuretic Peptide Level in Patients with Severe Heart Failure

  • Letter to the Editor
  • Published:
Cardiovascular Drugs and Therapy Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Johnston D,Duffin D. Drug-patient interactions and their relevance in the treatment of heart failure. Am J Cardiol 1992; 70: 109C-112C.

    Google Scholar 

  2. Przechera M,Roth W,Kühlkamp V,Risler T,Haehl M. Pharmacokinetic profile and tolerability of pimobendan in patients with terminal renal insufficiency. Eur J Clin Pharmacol 1991; 40: 107-111.

    Google Scholar 

  3. Shigematsu A,Kondo U,Aoyama K, et al. Phase I study of a heart failure drug, pimobendan capsules (UD-CG 115BS): Single oral doses of 1.25 mg, 2.5 mg, 5.0 mg, and 7.5 mg. Rinsyo to Kenkyu 1991; 68: 2154-2172 (in Japanese).

    Google Scholar 

  4. Walter M,Liebens I,Goethals H,Renard M,Dresse A,Bernard R. Pimobendan (UD-CG 115BS) in the treatment of severe congestive heart failure: An acute haemodynamic Pharmacokinetics of Pimobendan and BNP 293 cross-over and double-blind study with two different doses. Br J Clin Pharmacol 1988; 25: 323-329.

    Google Scholar 

  5. Hagemeijer F,Brand HJ,Roth W. Cardiovascular effects and plasma level profile of pimobendan (UD-CG 115 BS) and its metabolite UD-CG 212 in patients with congestive heart failure after single and repeated oral dosing. J Cardiovasc Pharmacol 1989; 14: 302-310.

    Google Scholar 

  6. Renard M,Walter M,Liebens I,Dresse A,Bernard R. Pimobendan (UD-CG 115BS) in chronic congestive heart failure: Short term and one-month effects of a new inotropic vasodilating agent. Chest 1988; 93: 1159-1164.

    Google Scholar 

  7. Chu KM,Shieh SM,Hu OYP. Pharmacokinetics and pharmacodynamics of enantiomers of pimobendan in patients with dilated cardiomyopathy and congestive heart failure after single and repeated oral dosing. Clin Pharmacol Ther 1995; 57: 610-621.

    Google Scholar 

  8. Kjæ A,Hesse B. Heart failure and neuroendocrine activation: Diagnostic, prognostic and therapeutic perspectives. Clin Pysiol 2001; 21: 661-672.

    Google Scholar 

  9. Mukoyama M,Nakao K,Saito Y, et al. Brain natriuretic peptide (BNP) as a novel cardiac hormone in humans: Evidence for an exquisite dual natriuretic peptide system, ANP and BNP. J Clin Invest 1991; 87: 1402-1412.

    Google Scholar 

  10. Wei CM,Heublein DM,Perrella MA, et al. Natriuretic peptide system in human heart failure. Circulation 1993; 88: 1004-1009.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wakaumi, M., Shiga, T., Naganuma, M. et al. Plasma Concentration Profile of Orally Administered Pimobendan and Plasma Brain Natriuretic Peptide Level in Patients with Severe Heart Failure. Cardiovasc Drugs Ther 17, 291–293 (2003). https://doi.org/10.1023/A:1026201029821

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026201029821

Navigation