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A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea


Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrheal days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.

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Correspondence to Ripudaman S. Beniwal.

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Beniwal, R.S., Arena, V.C., Thomas, L. et al. A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea. Dig Dis Sci 48, 2077–2082 (2003).

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  • effectiveness
  • yogurt
  • dietary intervention
  • biotherapeutics
  • prophylaxis
  • antibiotic-associated diarrhea