Skip to main content
SpringerLink
Log in

Induction of Dominant Lethals in Progeny of CBA Male Mice after Pheromonal Action

  • Published:
Russian Journal of Genetics Aims and scope Submit manuscript

Abstract

The inhibiting effect of pheromone 2,5-dimethylpyrazine of house mouse females on the reproductive function of the CBA male mice was studied. The mutagenic effect of six-day pheromonal treatment was assessed by dominant lethal test. Analysis for the frequency of dominant lethals showed that the pheromonal effect results in an increased death rate of the progeny of the treated males. This is probably explained by implantation failure and is expressed in a reduced average number of the implants and low live embryos per female. The proportion of females with live embryos decreased significantly. The implication of the effect of female mouse pheromone 2,5- dimethylpyrazine on the genetic processes in germ cells of male mice is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Stoddart, D.M., The Role of Odor in the Social Biology of Small Mammals, Pheromones, Birch, M.C., Ed., Amsterdam: North Holland, 1974, pp. 297–315.

    Google Scholar 

  2. Stoddart, D.M., Aspects of the Evolutionary Biology of Mammalian Olfaction, Symp. Zool. Soc., 1980, no. 45, pp. 1–13.

    Google Scholar 

  3. Bronson, F.H. and Macmillan, B., Hormonal Responses to Primer Pheromones, Pheromones and Reproduction in Mammals, Vandenbergh, J.G., Ed., New York: Academic, 1983, pp. 175–179.

    Google Scholar 

  4. Daev, E.V., Pheromonal Control of Genetic Processes: Studies in House Mouse Mus musculus L., Genetika (Moscow), 1994, vol. 30, no. 8, pp. 1105–1112.

    Google Scholar 

  5. Novikov, S.N., Daev, E.V., and Tsapygina, R.I., The Effect of Urinary Volatiles on the Germ Function of Juvenile Males in House Mouse Mus musculus L., Dokl. Akad. Nauk SSSR, 1985, vol. 281, pp. 1506–1508.

    Google Scholar 

  6. Aref'ev, A.A. and Daev, E.V., Impaired Spermatogenesis in House Mouse after Exposure to Urinary Volatiles of Mature Males, in Aktual'nye problemy sovremennoi biologii. Problemy differentsirovki i funktsionirovaniya kletok (Current Problems of Modern Biology: Problems of Cell Differentiation and Function), 1987, deposition no. 3107-B-87, pp. 29–40.

  7. Inge-Vechtomov, S.G., Barabanova, L.V., Daev, E.V., and Luchnikova, E.M., The Effect of Ecological Relationships on Genetic Processes, Vestn. St.-Peterburg.Univ., Ser. 3: Biol., 1999, no. 4, pp. 14–32.

    Google Scholar 

  8. Bruce, H.M., An Exteroceptive Block to Pregnancy in the Mouse, Nature, 1959, vol. 184, p. 105.

    Google Scholar 

  9. Marchlewska-Koj, A., Pregnancy Block Elicited by Urinary Proteins of Male Mice, Biol. Reprod., 1977, vol. 17, pp. 729–732.

    Google Scholar 

  10. Marchlewska-Koj, A., Jemiolo, B., Wozniacka, J., and Kozlowski, K., Male-Pheromone Effect on the Efficiency of Pregnancy in Female Mice, J. Reprod. Fert., 1980, vol. 58, pp. 363–367.

    Google Scholar 

  11. Sahu, S.C. and Dominic, C.J., Evidence for the Involvement of Serotoninergic System in the Male-Induced Ovo-Implantaiton Failure (Bruce-Effect) in Mice, Ann.d'Endocrinol., 1980, vol. 41, pp. 425–429.

    Google Scholar 

  12. Novonty, M., Jemiolo, B., and Harvey, S., Chemistry of Rodent Pheromones: Molecular Insight into Chemical Signaling in Mammals, Chemical Signals in Vertebrates, MacDonald, D.W., et al., Eds., Oxford: Oxford Univ. Press, 1990, pp. 1–22.

    Google Scholar 

  13. Novotny, M.V., Ma, W., Zidek, L., and Daev, E.V., Recent Biochemical Insights into Puberty Acceleration, Estrus Induction and Puberty Delay in the House Mouse, Advances in Chemical Signals in Vertebrates, Johnston, R., et al., Eds., New York: Kluwer Academic Plenum, 1999, pp. 99–116.

    Google Scholar 

  14. Jemiolo, B. and Novotny, M., Inhibition of Sexual Maturation in Juvenile Female and Male Mice by a Chemosignal of Female Origin, Physiol. Behav., 1994, vol. 55, pp. 519–522.

    Google Scholar 

  15. Buchbauer, G., Nikiforov, A., and Remberg, B., Headspace Constituents of Opium, Planta Med., 1994, vol. 60, no. 2, pp. 181–183.

    Google Scholar 

  16. Shibamoto, T., Heterocyclic Compounds Found in Cooked Meats, Agric. Food Chem., 1980, vol. 28, pp. 237–243.

    Google Scholar 

  17. Shimoda, M., Shiratsuchi, H., Nakada, Y., et al., Identification and Sensory Characterization of Volatile Flavor Compounds in Sesame Seed Oil, Agric. Food Chem., 1996, vol. 44, pp. 3909–3912.

    Google Scholar 

  18. Joo, K. and Ho, C.T., Quantitative Analysis of Alkylpyrazines in Regular-and Low-Fat Commercial Peanut Butter Preparations, Biosci. Biotechnol. Biochem., 1997, vol. 61, pp. 171–173.

    Google Scholar 

  19. Daev, E.V., Vorob'ev, K.V., Shustova, T.I., et al., Genotype-Specific Changes in Several Functional Parameters of Immunocompetent Cells in Male Laboratory Mice Exposed to Pheromone Stress, Genetika (Moscow), 2000, vol. 36, no. 8, pp. 1055–1060.

    Google Scholar 

  20. Daev, E.V., Vorob'ev, K.V., and Zimina, S.A., Olfactory Stress and Modification of Phagocytosis in Peripheral Blood Cells of Mature Male Mice, Tsitologiya, 2001, vol. 43, no. 10, pp. 954–960.

    Google Scholar 

  21. Aref'ev, A.A., Daev, E.V., Kaidanov, L.Z., et al., Abnormal Spermatogenesis in Laboratory Mice Exposed to Urinary Volatiles of Mature Males, Dokl. Akad. Nauk SSSR, 1986, vol. 291, pp. 1257–1259.

    Google Scholar 

  22. Novotny, M., Harvey, S.D., and Jemiolo, B., US Patent 5 252 326, 1993.

  23. Burnasheva, S.A., Gabaeva, N.S., Danilova, L.V., et al., {tiSovremennye problemy spermatogeneza (Modern Problems of Spermatogenesis)}, Moscow: Nauka, 1982.

  24. Clermont, Y., Kinetics of Spermatogenesis in Mammals: Seminiferous Epithelium Cycle and Spermatogonial Renewal, Physiol. Rev., 1972, vol. 52, pp. 198–236.

    Google Scholar 

  25. Oakberg, E., Duration of Spermatogenesis in the Mouse, Nature, 1957, vol. 180, pp. 1137–1158.

    Google Scholar 

  26. Oud, J.L. and Jong de Rooij, D.G., A Sequential Analysis of Meiosis in the Male Mouse Using a Restricted Spermatocyte Population Obtained by a Hydroxyurea/Triaziquone Treatment, Chromosoma, 1979, vol. 71, pp. 237–248.

    Google Scholar 

  27. Glotov, N.V., Zhivotovsky, L.A., Khovanov, N.V., and Khromov-Borisov, N.N., Biometriya (Biometry), Leningrad: Leningr. Gos. Univ., 1982.

    Google Scholar 

  28. Zaks, L., Statisticheskoe otsenivanie (Statistical Evaluation), Moscow: Statistika, 1976.

    Google Scholar 

  29. Podol'naya, M.A., Bobrinev, E.V., and Revazova, Yu.A., Analysis of Several Methods for Statistical Treatment of the Results Concerning Induction of Dominant Lethals in Mouse Germline Cells, Genetika (Moscow), 1981, vol. 17, no. 4, pp. 651–657.

    Google Scholar 

  30. Ehling, U.Z., Machemer, L., Busselmaier, W., et al., Standard Protocol for the Dominant Lethal Test on Male Mice, Arch. Tosicol., 1978, vol. 39, pp. 173–185.

    Google Scholar 

  31. Daev, E.V., Tsapygina, R.I., and Lopatina, N.G., Frequency of Dominant Lethals in the Progeny of Young Males of House Mouse Mus musculus L. after Exposure to Excretion Products of Mature Males of the Same Species, Genetika (Moscow), 1988, vol. 24, no. 11, pp. 2015–2021.

    Google Scholar 

  32. Lecyk, M., The Influence of Crowded Population Stimuli on the Development of Reproductive Organs in the Common Vole, Acta Theriol., 1967, vol. 12, pp. 177–179.

    Google Scholar 

  33. Christian, J.J., Effect of Population Size on the Weights of the Reproductive Organs of White Mice, Am. J. Physiol., 1955, vol. 181, pp. 477–480.

    Google Scholar 

  34. Christian, J.J., Effect of Population Size on the Adrenal Glands and Reproduction of Male Mice in Population at Fixed Size, Am. J. Physiol., 1955, vol. 182, pp. 282–300.

    Google Scholar 

  35. Lee, A.K. and McDonald, I.R., Stress and Population Regulation in Small Mammals, Oxford Rev. Reprod. Biol., 1985, vol. 7, pp. 261–304.

    Google Scholar 

  36. Moshkin, M.P., Kolosova, I.E., Novikov, Eu.A., et al., Co-Modulation of the Immune Function and the Reproductive Chemosignal, Asian-Aust. J. Anim. Sci., 2001, vol. 14, special issue, pp. 43–51.

    Google Scholar 

  37. Koyama, S. and Kamimura, S., Influence of Social Dominance and Female Odor on the Sperm Activity of Male Mice, Physiol. Behav., 2000, vol. 71, pp. 415–422.

    Google Scholar 

  38. Brown, R.E., The Rodents: I. Effects of Odors on Reproductive Physiology (Primer Effects), Social Odors in Mammals, Brown, R.E. and MacDonald, D.W., Eds., Oxford: Clarendon, 1985, pp. 245–344.

    Google Scholar 

  39. Ader, R., Psychoneuroimmunology, Curr. Direct. Psychol. Sci., 2001, vol. 10, pp. 94–98.

    Google Scholar 

  40. Ader, R., Madden, K., Felten, D., et al., Psychoneuroimmunology: Interaction between the Brain and the Immune System, Neuropsychiatry,Fogel, B.S. et al., Eds., Philadelphia: Williams and Wilkins, 1996, pp. 193-221.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics and Breeding, St. Petersburg State University, St. Petersburg, 199034, Russia

    E. V. Daev

Authors
  1. E. V. Daev
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Daev, E.V. Induction of Dominant Lethals in Progeny of CBA Male Mice after Pheromonal Action. Russian Journal of Genetics 39, 1138–1143 (2003). https://doi.org/10.1023/A:1026122926802

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026122926802

Keywords

Search

Navigation