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Synthesis of New 3-Aryl-1-methylbenzo[f]quinolines

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Abstract

Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.

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Kozlov, N.G., Basalaeva, L.I. Synthesis of New 3-Aryl-1-methylbenzo[f]quinolines. Russian Journal of Organic Chemistry 39, 718–722 (2003). https://doi.org/10.1023/A:1026077716902

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