Skip to main content
Log in

Alteration of the Liver in Rats with Experimental Dysbiosis

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

We evaluated the relationship between pathological changes in the liver and the state of intestinal microflora in rats with experimental dysbiosis. Changes in the intestinal microflora were accompanied by alteration of the morphological structure in the liver. Enhanced proliferation of Ito cells served as an indirect evidence of damage to the liver. Ito cells did not undergo transformation into myofibroblasts that excluded the possibility of fibrosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. Manual on Antibacterial Therapy [in Russian], Eds. L. S. Strachunskii et al., Moscow (2000).

  2. I. M. Salakhov, A. S. Sozinov, S. R. Abdulkhakov, et al., Byull. Eksp. Biol. Med., 130, No. 10, 449-453 (2000).

    Google Scholar 

  3. J. H. Chuang, W. J. Chen, S. K. Lo, and N. K. Chang, JPEN J. Parenter. Enteral. Nutr., 21, No. 1, 36-40 (1997).

    Google Scholar 

  4. R. P. Cornell, L. Liljequist, and K. F. Bartizal, Hepatology, 11, No. 6, 916-922 (1990).

    Google Scholar 

  5. N. Fausto and E. M. Webber, The Liver: Biology and Pathobiology, New York (1994), pp. 1059-1084.

  6. M. Ferri, S. Gabriel, A. Gavelli, et al., Arch. Surg., 132, No. 2, 162-165 (1997).

    Google Scholar 

  7. K. Fujio, R. P. Evarts, Z. Hu, et al., Lab. Invest., 70, 511-516 (1994).

    Google Scholar 

  8. T. Higashiguchi, A. Ito, M. Kitagawa, et al., J. Hepat. Biliary Pancreatic Surg., 3, No. 3, 291-296 (1996).

    Google Scholar 

  9. L. Lora, E. Mazzon, D. Martines, et al., Gastroenterology, 113, No. 4, 1347-1354 (1997).

    Google Scholar 

  10. A. Martinez-Hernandez and P. S. Amenta, Virchows Arch. [A], 423, 77-84 (1993).

    Google Scholar 

  11. G. Ramadori, K. Neubauer, M. Odenthal, et al., Biochem. Biophys. Res. Commun., 183, No. 2, 739-742 (1992).

    Google Scholar 

  12. P. Schirmacher, A. Geerts, W. Jung, et al., EXS, 65, 285-299 (1993).

  13. C. Schmidt, F. Bladt, S. Goedecke, et al., Nature, 373, No. 6516, 699-702 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. S. Sozinov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sozinov, A.S., Abdulkhakov, S.R., Kiyasov, A.P. et al. Alteration of the Liver in Rats with Experimental Dysbiosis. Bulletin of Experimental Biology and Medicine 136, 19–21 (2003). https://doi.org/10.1023/A:1026020325603

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026020325603

Navigation