Relationship between Glutathione S-Transferase P1 Polymorphism and Bronchial Asthma and Atopic Dermatitis

  • O. G. Safronova
  • V. A. Vavilin
  • A. A. Lyapunova
  • S. I. Makarova
  • V. V. Lyakhovich
  • L. F. Kaznacheeva
  • N. A. Manankin
  • O. A. Batychko
  • S. M. Gavalov
Article

Abstract

We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).

bronchial asthma atopic dermatitis xenobiotics glutathione S-transferase P1 polymorphism predisposition 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • O. G. Safronova
    • 1
  • V. A. Vavilin
    • 1
    • 2
    • 3
  • A. A. Lyapunova
    • 1
    • 2
    • 3
  • S. I. Makarova
    • 1
    • 2
    • 3
  • V. V. Lyakhovich
    • 1
    • 2
    • 3
  • L. F. Kaznacheeva
    • 1
    • 2
    • 3
  • N. A. Manankin
    • 1
    • 2
    • 3
  • O. A. Batychko
    • 1
    • 2
    • 3
  • S. M. Gavalov
    • 1
    • 2
    • 3
  1. 1.Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and BiophysicsRussia
  2. 2.Novosibirsk State Medical AcademyRussia
  3. 3.Municipal Children's Hospital No. 1Novosibirsk

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