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Neuroleptic malignant syndrome in juvenile neuronal ceroid lipofuscinosis associated with low-dose risperidone therapy

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Journal of Inherited Metabolic Disease

Abstract

Summary:#We present a patient with juvenile neuronal ceroid lipofuscinosis who developed a neuroleptic malignant syndrome when treated for hallucinations with a very low dose of risperidone, an atypical neuroleptic medication with usually few extrapyramidal side-effects. The loss of dopaminergic neurons in this condition may make these patients more vulnerable to this severe adverse effect.

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Authors and Affiliations

  1. Departments of Pediatrics and Neurology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium

    L. Vercammen, G. M. Buyse, J. E. F. Proost, J. L. K. Van Hove & J. L. K. Van Hove

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  1. L. Vercammen
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  2. G. M. Buyse
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  3. J. E. F. Proost
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  4. J. L. K. Van Hove
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Vercammen, L., Buyse, G.M., Proost, J.E.F. et al. Neuroleptic malignant syndrome in juvenile neuronal ceroid lipofuscinosis associated with low-dose risperidone therapy. J Inherit Metab Dis 26, 611–612 (2003). https://doi.org/10.1023/A:1025916518457

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  • DOI: https://doi.org/10.1023/A:1025916518457

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