Abstract
In this paper the structural characterization of terfenadine crystallized from ethanol-water, ethanol and methanol is performed by infrared spectroscopy. The OH stretching vibration, composed of three markedly overlapped bands, is analyzed by peak fitting. The assignment of the hydrogen bonds was conducted making use of band parameters, spectroscopic data for CCl4 solutions, and molecular dynamics calculations from dimeric systems. Terfenadine just precipitated from solvents is never in the highest crystalline state. This state is reached when the samples are heated at a temperature above 100°C. Some amorphous solid is coprecipitated with the crystalline phase, particularly in methanol.
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References
J. Tomkinson, Spectrochim. Acta, 48A (1992) 329.
G. A. Jefrey, An Introduction to Hydrogen Bonding, Oxford University Press, New York 1997.
G. R. Desiraju and T. Steiner, The Hydrogen Bond, Oxford University Press, New York 1999.
R. M. Badger and S. M. Bauer, J. Chem. Phys., 5 (1937) 839.
M. D. Joesten and L. J. Schaad, Hydrogen Bonding, Marcel Dekker, Inc., New York 1974.
A. V. Iogansen, Spectrochim. Acta, 55A (1999) 1585.
J. M. Rollinger and Cs. Novák (Ed.), J. Therm. Anal. Cal., 68 (2002) 335.
M. L. P. Leitão, J. Canotilho, S. C. R. Ferreira, A. T. Sousa and J. S. Redinha, submitted to Thermochim. Acta.
K. Kiss-Eröss, Analytical Infrared Spectroscopy in Comprehensive Analytical Chemistry, Vol. VI, Elsevier Scientific Publ. Co., Amsterdam 1976.
W. F. Maddams, Appl. Spectrosc., 34 (1980) 245.
E. Fishman and T. L. Chen, Spectrochim. Acta, 25A (1969) 1231.
L. P. Kuhn, J. Am. Chem. Soc., 74 (1952) 2492.
Y. Nakao, H. Sugeta and Y. Kyogoku, Spectrochim. Acta, 42A (1986) 251.
R. V. Pappu, R. K. Hart and J. W. Ponder, J. Phys. Chem., B 102 (1998) 9725.
J. Lii and N. L. Allinger, J. Comput. Chem., 19 (1998) 1001.
A. F. Sousa, J. Canotilho, A. A. C. C. Pais, M. L. P. Leitão and J. S. Redinha, Molecular Physics, in press.
M. L. P. Leitão, J. Canotilho, M. S. C. Cruz, J. C. Pereira, A. T. Sousa and J. S. Redinha, J. Therm. Anal. Cal., 68 (2002) 397.
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Leităo, M.L.P., Canotilho, J., Sousa, A. et al. Infrared spectroscopy and the characterization of terfenadine crystallized from solvents. Journal of Thermal Analysis and Calorimetry 73, 763–774 (2003). https://doi.org/10.1023/A:1025826329359
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DOI: https://doi.org/10.1023/A:1025826329359