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Introduction: A Close Look at the Vacuolar ATPase

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Abstract

The vacuolar ATPases (V-type ATPases) are a family of ATP-dependent ion pumps and found in two principal locations, in endomembranes and in plasma membranes. This family of ATPases is responsible for acidification of intracellulare compartments and, in certain cases, ion transport across the plasma membrane of eucaryotic cells. V-ATPases are composed of two distinct domains: a catalytic V1 sector, in which ATP hydrolysis takes place, and the membrane-embedded sector, V0, which functions in ion conduction. In the past decade impressive progress has been made in elucidating the properties structure, function and moleculare biology. These knowledge sheds light also on the evolution of V-ATPases and their related families of A-(A1A0-ATPase) and F-type (F1F0-ATPases)ATPases.

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References

  • Abrahams, J. P., Leslie, A. G. W., Lutter, R., and Walker J. E. (1994). Nature 370, 621–628.

    PubMed  Google Scholar 

  • Boekema, E. J., Ubbink-Kok, T., Lolkema, J. S., Brisson, A., and Konings, W. N. (1998). Photosyn. Res. 57, 267–273.

    Google Scholar 

  • Domgall, I., Venzke, D., Lüttge, U., Ratajczak, R., and Böttcher, B. (2002). J. Biol. Chem. 277, 13115–13121.

    PubMed  Google Scholar 

  • Graham, L. A., Hill, K. J., and Stevens, T. H. (1998). J. Cell Biol. 142, 39–49.

    PubMed  Google Scholar 

  • Grüber, G., Godovac-Zimmermann, J., Link, T. A., Coskun, ü., Rizzo, V. F., Betz, C., and Bailer, S. M. (2002). Biochem. Biophys. Res. Commun. 298, 383–391.

    PubMed  Google Scholar 

  • Grüber, G., Radermacher, M., Ruiz, T., Godovac-Zimmermann, J., Canas, B., Kleine Kohlbrecher, D., Huss, M., Harvey, W. R., and Wieczorek, H. (2000). Biochemistry 39, 8609–8616.

    PubMed  Google Scholar 

  • Grüber, G., Wieczorek, H., Harvey, W. R., and Müller, V. (2001). J. Exp. Biol. 204, 2597–2605.

    PubMed  Google Scholar 

  • Hilario, E., and Gogarten, J. P. (1998). J. Mol. Evol. 46, 703–715.

    PubMed  Google Scholar 

  • Hirata, R., Graham, L. A., Takatsuki, A., Stevens, T. H., and Anraku, Y. (1997). J. Biol. Chem. 272, 4795–4803.

    PubMed  Google Scholar 

  • Hirata, T., Iwamoto-Kihara, A., Sun–Wada, G.-H., Okajima, T., Wada, Y., and Futai, M. (2003) J. Biol. Chem. 278, 23714–23719.

    PubMed  Google Scholar 

  • Holliday, L. S., Lu, M., Lee, B. S., Nelson, R. D., Solivan, S., Zhang, L., and Gluck, S. L. (2000). J. Biol. Chem. 275, 32331–32337.

    PubMed  Google Scholar 

  • Kakinuma, Y., and Igarashi, K. (1995). FEBS Lett. 359, 255–258.

    PubMed  Google Scholar 

  • Kane, P. M. (1995). J. Biol. Chem. 270, 17025–17032.

    PubMed  Google Scholar 

  • Kane, P. M., and Parra, K. J. (2000). J. Exp. Biol. 203, 81–87.

    PubMed  Google Scholar 

  • Kawasaki-Nishi, S., Nishi, T., and Forgac, M. (2001). Proc. Natl. Acad. Sci. U.S.A. 98, 12397–12402.

    PubMed  Google Scholar 

  • Landolt-Marticorena, C., Williams, K. M., Correa, J., Chen, W., and Manolson, M. F. (2000). J. Biol. Chem. 275, 15449–15457.

    PubMed  Google Scholar 

  • Ludwig, J., Kerscher, S., Brandt, U., Pfeiffer, K., Getlawi, F., Apps, D. K., and Schägger, H. (1998). J. Biol. Chem. 273, 10939–10947.

    PubMed  Google Scholar 

  • Mandel, M., Moriyama Y., Hulmes, J. D., Pan, Y.-C. E., Nelson, H., and Nelson, N. (1988). Proc. Natl. Acad. Sci. U.S.A. 85, 5521–5524.

    PubMed  Google Scholar 

  • Merzendorfer, H., Huss, M., Schmid, R., Harvey, W. R., and Wieczorek H. (1999). J. Biol. Chem. 274, 17372–17378.

    PubMed  Google Scholar 

  • Müller, V., and Grüber, G. (2003). Cell Mol. Life Sci. 60, 474–494.

    PubMed  Google Scholar 

  • Murata, T., Arechaga, I., Fearnley, I. M., Kakinuma, Y., Yamato, I., and Walker, J. E. (2003) J. Biol. Chem. 278, 21162–21167.

    PubMed  Google Scholar 

  • Murata, T., Takase, K., Yamato, I., Igarashi, K., and Kakinuma, Y. (1999). J. Biochem. (Tokyo) 125, 414–421.

    Google Scholar 

  • Nelson, N. (1992) Biochim. Biophys. Acta 1100, 109–124.

    PubMed  Google Scholar 

  • Nelson, N., and Harvey, W. R. (1999). Physiol. Rev. 79, 361–385.

    PubMed  Google Scholar 

  • Nishi, T., and Forgac, M. (2002). Nat. Rev. Mol. Cell Biol. 3, 94–103.

    PubMed  Google Scholar 

  • Radermacher, M., Ruiz, T., Harvey, W. R., Wieczorek, H., and Grüber, G. (1999) FEBS Lett. 453, 383–386.

    PubMed  Google Scholar 

  • Radermacher, M., Ruiz, T., Wieczorek, H., and Grüber, G. (2001). J. Struct. Biol. 135, 26–37.

    PubMed  Google Scholar 

  • Sagermann, M., Stevens, T. H., and Matthews, B. W. (2001). Proc. Natl. Acad. Sci. U.S.A. 98, 7134–7139.

    PubMed  Google Scholar 

  • Speelmans, G., Poolman, B., Abee, T., and Konings, W. N. (1994). J. Bacteriol. 176, 5160–5162.

    PubMed  Google Scholar 

  • Sumner, J. P., Dow, J. A. T., Earley, F. G., Klein, U., Jäger, D., and Wieczorek, H. (1995). J. Biol. Chem. 270, 5649–5653.

    PubMed  Google Scholar 

  • Svergun, D. I., Konrad, S., Huss, M., Koch, M. H., Wieczorek, H., Altendorf, K., and Grüber, G. (1998). Biochemistry 37, 17659–17663.

    PubMed  Google Scholar 

  • Vitavska, O., Wieczorek, H., and Merzendorfer, H. (2003). J. Biol. Chem. 278, 18499–18505.

    PubMed  Google Scholar 

  • Wieczorek, H., Brown, D., Grinstein, S., Ehrenfeld, J., and Harvey, W. R. (1999). Bioessays 21, 637–648.

    PubMed  Google Scholar 

  • Wilkens, S. (2001). Cell Biochem. Biophys. 34, 191–208.

    PubMed  Google Scholar 

  • Wilkens, S., Vasilyeva, E., and Forgac, M. (1999). J. Biol. Chem. 274, 31804–31810.

    PubMed  Google Scholar 

  • Xu, T., Vasilyeva, E., and Forgac, M. (1999). J. Biol. Chem. 274, 28909–28915.

    PubMed  Google Scholar 

  • Xu, T. and Forgac, M. (2001). J. Biol. Chem. 276, 24855–24861.

    PubMed  Google Scholar 

  • Yoshida, M., Muneyuki, E., and Hisabori, T. (2001). Nat. Rev. Mol. Cell Biol. 2, 669–677.

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Universität des Saarlandes, Universitätsbau 76, Fachrichtung 2.5-Biophysik, D-66421, Homburg, Germany

    Gerhard Grüber

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  1. Gerhard Grüber
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Grüber, G. Introduction: A Close Look at the Vacuolar ATPase. J Bioenerg Biomembr 35, 277–280 (2003). https://doi.org/10.1023/A:1025795612839

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