Abstract
The aim of this study is to design an effective hydrogel, which has good potential for application in the field of tissue regeneration. Ultimately, the polymeric biomaterial will be used as a bottom, non-cell adhering layer of a polymeric scaffold, which will inhibit the adhesion and proliferation of fibroblast cells. A series of terpolymer hydrogels were prepared from MMA/HPOEM/MePOEM monomers based on varying formulations. The gels were polymerized via free radical polymerization under UV and characterized by TGA, DSC and FTIR studies. Furthermore, the double bond conversion, gel content and swelling properties of the polymer were analyzed and correlated to its crosslinking density, which revealed details about the hydrogel’s character. Finally, cell culture experiments were used to compare the UV-cured polymer to its thermally derived non-functionalized polymer of the same formulation. Inverted optical microscopy was used to demonstrate cell-resistance of both materials with respect to a control Tissue Culture PolyStyrene plate. ©2003 Kluwer Acadamic Publishers
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http://www.materials.drexel.edu/LBTE%20website/Biomaterials.html, under the leadership of Dr Michele Marcolongo.
C. J. De Groot, M. J. A. Van Luyn, W. N. E. Van Dijk-Wolthuis, J. A. Cadee, J. A. Plantinga, W. Den Otter and W. E. Hennink, Biomaterials 22 (2001) 1197.
H. Park and K. Park, in ‘Biocompatibility issues of implantable drug delivery systems’ Pharm. Res. 13 (1996) 1770.
R. H. Schmedlen, K. S. Masters and J. L. West, Biomaterials 23 (2002) 4325.
B. K. Mann, A. S. Gobin, A. T. Tsai, R. H. Schmedlen and J. L. West, ibid. 22 (2001) 3045.
D. J. Irvine and A. M. Mayes, Biomacromolecules 2 (2001) 85.
J. Hyun, H. Ma, P. Banerjee, J. Cole, K. Gonsalves and A. Chilkoti, Langmuir 18 (2002) 2975.
B. K. Mann, A. T. Tsai, T. Scott-Burden and J. L. West, Biomaterials 20 (1999) 2281.
C. R. Nuttelman, S. M. Henry and K. S. Anseth, ibid. 23 (2002) 3617.
B. D. Ratner, in ‘Biocompatibility of clinical implant materials, vol II’, edited by D. F. Williams (CRC Press, Boca Raton, Florida, 1981) chapter 7.
J. M. Rosiak and F. Yoshii, Nucl. Instrum. Methods Phys. Res. 151 (1999) 56.
M. Azam Ali, T. L. Ooi, A. Salmiah, U. S. Ishiaku and Z. A. Mohd Ishak, J. Appl. Polym. Sci. 79 (2001) 2156.
M. A. Sabino, J. L. Feijoo, O. Nunez and D. J. Ajami, J. Mater Sci. 37 (2002) 35.
K. C. Olbrich, T. T. Andersen, F. A. Blumenstock and R. Bizios, Biomaterials 17 (1996) 759.
A. Priola, G. Gozzelino, F. Ferrero and G. Malucelli, Progress in Organic Coatings 22 (1993) 301.
J. Pionteck, S. Richter, S. Zschoche, K. Sahre and K. F. Arndt, Acta Polymer 49 (1998) 192.
W. F. Lee and Y. H. Lin, J. Appl. Polym. Sci. 81 (2001) 1360.
W. F. Lee and Y. H. Lin, ibid. 77 (2000) 1769.
L. Y. Shieh and N. A. Peppas, ibid. 42 (1991) 1579.
N. M. Franson and N. A. Peppas, ibid. 28 (1983) 1299.
R. W. Korsmeyer, E. W. Meerwall and N. A. Peppas, J. Polym. Sci. Polym. Phys. Ed. 24 (1986) 409.
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Delmar-Greenberg, D., Azam Ali, M. & Gonsalves, K.E. Non cell adhesive photopolymerized cross-linked layers (I): synthesis and characterization. Journal of Materials Science: Materials in Medicine 14, 833–841 (2003). https://doi.org/10.1023/A:1025670323657
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DOI: https://doi.org/10.1023/A:1025670323657