Abstract
Dense fluorine (F) substituted hydroxyapatite composites with yttria-doped zirconia (Y-TZP) and/or alumina (Al2O3) were successfully fabricated without applying pressure at 1400 °C for 3 h. The suppression of decomposition via the formation of a fluor-hydroxyapatite (FHA) solid solution allowed the sintered body to reach full density. Such fully densified FHA-composites exhibited improved mechanical properties, such as strength, toughness, and hardness, having values of more than ∼2–4 times higher than those of pure HA or HA-composites. The proliferation behavior of osteoblast-like cells on the FHA-composites showed no cytotoxicity and comparable cell viability to that observed in pure HA for up to 10 days.
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Kim, HW., Noh, YJ., Koh, YH. et al. Enhanced performance of fluorine substituted hydroxyapatite composites for hard tissue engineering. Journal of Materials Science: Materials in Medicine 14, 899–904 (2003). https://doi.org/10.1023/A:1025638811361
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DOI: https://doi.org/10.1023/A:1025638811361