Abstract
Genetic and environmental influences in the determination of individual differences in self-reported symptoms of separation anxiety (SAD), overanxious disorder (OAD), and manifest anxiety (MANX) were evaluated in children and adolescents for three age groups (8–10, 11–13, and 14–16). Symptom counts for SAD and OAD were assessed for 1412 twin pairs using the children's version of the Child and Adolescent Psychiatric Assessment, and MANX scores were based on child report from the Revised Children's Manifest Anxiety Scales. Despite significant age and gender differences in thresholds of liability for child reports of symptoms of SAD and OAD, additive genetic and environmental effects could be set equal across age and gender for these variables. For MANX, however, the best-fitting model was a common effects sex-limitation model with estimates of heritabiliry varying dependent upon age and gender. Parameter estimates from the ACE models of OAD and SAD showed that additive genetic variation was a necessary component in the explanation of individual differences in child-reported symptoms of OAD (h 2 = .37) across gender, but does not appear to be a major contributor to the explanation of individual differences in symptoms of SAD reported by children. Shared environmental effects (c 2 = .40) were found to play a moderate role for SAD but could be dropped from the model for OAD and from all of the age groups for MANX, although the parameter approached significance among 11 yr to 13-year-old males.
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REFERENCES
American Psychiatric Association (1987). DSM-Hl-R. Diagnostic and Statistical Manual of Mental Disorders, 3rd cd., rev., APA, Washington, DC, pp. 50-57.
Anderson, J., Williams, S., McGee, R., and Silva, P. (1989). Cognitive and social correlates of DSM-III disorders in preadolescent children. J. Am. Acad. Child Adolesc. Psychiatry 28:842-846.
Angold, A., Cox, A., Pendergast, M., Rutter, M., and Simonoff, E. (1989). The Child and Adolescent Psychiatric Assessment, MRC Child Psychiatry Unit, University of London, London, and Developmental Epidemiology Program, Duke University, Durham, NC.
Angold, A., Pendergast, M., Cox, A., Harrington, R., Simonoff, E., and Rutter, M. (1995). The child and adolescent psychiatric assessment. Psychol. Med. 25:729-753.
Bell-Dolan, D. J., Last, C. G., and Strauss, C. C. (1990). Symptoms of anxiety disorders in normal children. J. Am. Acad. Child Adolesc. Psychiatry 29:759-765.
Bernstein, G. A., and Borchardt, C. M. (1991). Anxiety Disorders of childhood and adolescence: A critical review. J. Am. Acad. Child Adolesc. Psychiat. 30:519-532.
Bird, H. R., Gould, M. S., Yager, T,, Staghezza, B., and Canino, G. (1989). Risk factors for maladjustment in Puerto Rican children. J. Am. Acad. Child Adolesc. Psychiatry 28:847-850.
Bouchard, T. J. (1994). Genes, environment, and personality. Science 264:1700-1701.
Bowen, R. C., Offord, D. R., and Boyle, M. H. (1990). The prevalence of overanxious disorder and separation anxiety disorder: Results from the Ontario child health study. J. Am. Acad. Child Adolesc. Psychiatry 29:753-758.
Broadhurst, P. L. (1960). Applications of biomerrical genetics to the inheritance of behavior. In Eysenck, H. J. (ed.), Experiments in Personality, pp. 3-71.
Clark, D. B., Smith, M. G., Neighbors, B. D., Skerlec, L. M., and Randall, J. (1994). Anxiety disorders in adolescence: Characteristics, prevalence, and cornorbidities. Clin. Psychol. Rev. 14:113-137.
Cohen, P., Cohen, J., Dasen, S., Velez, C. N., Hartmark, C., Johnson, J., Rojas, M., Brook, J., and Streuning, E. L. (1993). An epidemiological study of disorders in late childhood and adolescence. I, Age-and gender-specific prevalence.J. Child Psychol. Psychiatry 34:851-867.
Costello, E. J. (1989a). Developments in child psychiatric epidemiology. J. Am. Acad. Child Adolesc. Psychiatry 28: 836-841.
Costello, E. J. (1989b). Child psychiatric disorders and theircorrelates: A primary care pediatric sample. J. Am. Acad.Child Adolesc. Psychiatry 28:851-855.
Eaves, L, J., Eysenck, H. J., and Martin, N. G. (1989). Genes, Culture and Personality, Academic Press, London.
Edelbrock, C., Costello, A. J., Dulcan, M. K., Conover, N. C., and Kala, R. (1986). Parent-child agreement on childpsychiatric symptoms assessed via structured interview. J. Child Psychol. Psychiatry 27:181-190.
Eysenck, H. J. (1982). Development of a theory. In Spielberger, C. S. (ed.), Personality. Genetics, and Behavior, Praeger, New York, pp. 1-48.
Faust, J., and Melamed, B. (1984). Influence of arousal, previous experience, and age on surgery preparation of same day of surgery and in-hospital pediatric patients.J. Consult. Clin. Psychol. 52:359-365.
Fendrich, M., Warner, V., and Weissman, M. M. (1990). Family risk factors, parental depression and psychopathology in offspring. Dev. Psychol. 26:40-50.
Flint, J., Corley, R., DeFries, J. C., Fulker, D. W., Gray, J. A., Miller, S., and Collins, A. C. (1995). A simple genetic basis for a complex psychological trait in laboratory mice. Science 269:1432-1435.
Fyer, A. J., Mannuzza, S., Chapman, T. F., Martin, L. Y., and Klein, D. F. (1995). Specificity in familial aggregation of phobic disorders. Arch. Gen. Psychiatry 52:564-572.
Gittelman, R., and Klein, D. F. (1985). Childhood separation anxiety and adult agoraphobia. In Tuma, A. H., and Masser, J. D. (eds.). Anxiety and the Anxiety Disorders. Erlbaum & Associates, Hillsdale, NJ, pp. 389-402.
Hewitt, J. K., Silberg, J. L., Rutter, M., Simonoff, E., Meyer, J. M., Maes, H., Pickles, A., Neale, M. C., Loeber, R., Erickson, M. T., Kendler, K. S., Heath, A. C., Truett, K. R., R eynolds, C. A., and Eaves, L. J. (1996). Genetics and developmental psychopathology: 1. Phenotypic assessment in the Virginia twin study of adolescent behavioral development (submitted for publication).
Jardine, R., Martin, N. G., and Henderson, A. S. (1984). Genetic covariation between neuroticism and the symptoms of anxiety and depression. Gen. Epidemiol. 1:89-107.
Kashani, J. H., and Orvaschel, H. (1990). A community study of anxiety in children and adolescents.Am. J. Psvchiatry 147:313-318.
Kendler, K., S., Heath, A. C., Martin, N. G., and Eaves, L. J. (1987). Symptoms of anxiety and symptoms of depression: Same genes, different environments? Arch. Gen. Psvchiatry 44:451-457.
Kendler, K. S., Neale, M. C., Kessler, R. C,, Heath, A. C., and Eaves, L. J. (1992). Major depression and generalized anxiety disorder: Same genes, (partly) different environments? Arch. Gen. Psychiatry 49:716-722.
Kendler, K. S., Heath, A. C., Neale, M. C., Kessler, R. C., and Eaves, L. J. (1993). Alcoholism and major depression in women. Arch. Gen. Psychiatry 50:690-698.
Kendler, K. S., Walters, E. E., Neale, M. C., Kessler, R. C., Heath, A. C., and Eaves, L. J, (1995). The structure of the genetic and environmental risk factor for six major psychiatric disorders in women. Arch. Gen. Psychiatry 52:374-383.
Kessler, R. C., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Eshleman, S., Wittchen, H.-U., and Kendler, K. S. (1994). Lifetime and 12-month prevalence of DSMIII-R psychiatric disorders in the United States.Arch. Gen. Psychiatry 51:8-19.
Last, C. G., Strauss, C. C., Hersen, M., Francis, G., and Grubb, H. J. (1987a). Psychiatric illness in mothers of anxious children.Am. J. Psychiatry 144:1580-1583.
Last, C. G., Phillips, J. E., and Statfeld, A. (1987b). Childhood anxiety disorders in mothers and their children. Child Psychiatry Hum. Dev. 18:103-112.
Loehlin, J. C., Willetroan, L., and Horn, J. M. (1987). Personality resemblance in adoptive families: A ten year followup. J. Person. Soc. Psychol. 53:961-969.
Neale, M. C. (1991). Mx: Statistical Modeling, 2nd ed., Box 710, Department of Psychiatry, MCV, Richmond, VA 23298.
Neale, M. C., and Cardon, L. R. (1992). Methodology for Genetic Studies of Twins and Families, Kluwer Academic, Boston.
Reynolds, C. R., and Richmond, B. O. (1978). What I think and feel: A revised measure of children's manifest anxiety.J. Abnorm. Child Psychol. 6:271-280.
Reynolds, C. R., and Richmond, B. O. (1985). Revised Children 's Manifest Anxiety Scale Manual, Western Psychological Services, Los Angeles.
Rosenhan, D. L., and Seligman, M. E. P. (1989). Abnormal Psychology, 2nd ed., W. W. Newton, New York, pp. 530-531.
Roy, M.-A., Neale, M. C., Pedersen, N. L., Mathe, A. A., and Kendler, K. S. (1995). A twin study of generalized anxiety disorder and major depression. Psychol. Med. 25: 1037-1049.
Russo, M. F., and Beidel, D. C. (1994). Comorbidity of childhood anxiety and externalizing disorders: Prevalence, associated characteristics and validation issues. Clin. Psychol. Rev. 14:199-221.
Rutter, M., MacDonald, H., Le Couteur, A., Harrington, R., Bolton, P., and Bailey, A. (1990). Genetic factors in child psychiatric disorders. II. Empirical findings. J. Child Psychol. Psychiatry 31:39-83.
Sapolsky, R. M. (1990). Stress in the wild: Studies of freeranging baboons in an African reserve are helping to explain why human beings can differ in their vulnerability to stress-related diseases. Sci. Am. 116-123.
Silove, D., Manicavasagar, V., O'Connell, D., and Yates, A. (1995). Genetic factors in early separation anxiety: Implications for the genesis of adult anxiety disorders. Acta Psychiatrica Scand. 92:17-24.
Simonoff, E., Pickles, A., Meyer, J. M., Silber, J. L., Maes, H. H., Loeber, R., Rutter, M., Hewitt, J. K., and Eaves, L. J. (1996). Epidemiology in the Virginia twin study of adolescent behavioral development: Influences of age, gender, and impairment on rates of disorder (submitted for publication).
Skre, I., Onstad, S., and Torgersen, S. (1993). A twin study of DSM-III-R (1987) anxiety disorders.Acta Psychiatrica Scand. 88:85-92.
Slosson, R. L. (1963). Slosson Oral Reading Test (SORT), Slosson. Educational, East Aurora, NY.
Stevenson, J., Batten, N., and Chemer, M. (1992). Fears and fearfulness in children and adolescents: A genetic analysis of twin data. J. Child Psychol. Psychiatry 33:977-985.
Suomi, S. J. (1981). Inherited and experiential factors associated with individual differences in anxious behavior displayed in rhesus monkeys. In Klein, D. F., and Rabkin, J. G. (eds.). Anxiety: New Research and Changing Concepts, Raven Press, New York, pp. 179-199.
Tannenbaum, Lynne E., Forehand, R., and Thomas, A. M. (1992). Adolescent self-reported anxiety and depression: Separate constructs or a single entity. Child Study J. 22: 61-72.
Thapar, A., and McGuffin, P. (1995). Are anxiety symptoms in childhood heritable? J. Child Psychol. Psychiatry 36: 439-447.
Velez, C. N., Johnson, J., and Cohen, P. (1989). A longitudinal analysis of selected risk factors for childhood psychopathology. J. Am. Acad. Child Adolesc. Psychiatry 28:861-864.
Simonoff, E., Pickles, A., Meyer, J. M., Silber, J. L., Maes, H. H., Loeber, R., Rutter, M., Hewitt, J. K., and Eaves, L, J. (1996). Epidemiology in the Virginia twin study of adolescent behavioral development: Influences of age, gender, and impairment on rates of disorder (submitted for publication).
Warner, V., Mufson, L., and Weissman, M. M. (1995). Offspring at high and low risk for depression and anxiety: Mechanisms of psychiatric disorder. J. Am. Acad. Child Adolesc. Psychiatry 34:786-797.
Weissman, M. M., and Olfson, M. (1995). Depression in women: Implications for health care research. Science 269:799-801.
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Topolski, T.D., Hewitt, J.K., Eaves, L.J. et al. Genetic and Environmental Influences on Child Reports of Manifest Anxiety and Symptoms of Separation Anxiety and Overanxious Disorders: A Community-Based Twin Study. Behav Genet 27, 15–28 (1997). https://doi.org/10.1023/A:1025607107566
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DOI: https://doi.org/10.1023/A:1025607107566
- Manifest anxiety
- separation anxiety
- overanxious disorder
- child reports
- genetic influences
- environmental influences
- twin study