Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells

Abstract

Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism.

This is a preview of subscription content, access via your institution.

REFERENCES

  1. 1.

    S. V. Anisimov, K. P. Bokheler, V. Kh. Khavinson, and V. N. Anisimov, Byull. Eksp. Biol. Med., 133,No. 3, 340-347 (2001).

    Google Scholar 

  2. 2.

    S. V. Rozenfel'd, E. F. Togo, V. S. Mikheev, et al., Ibid., 320-322.

  3. 3.

    V. Kh. Khavinson, T. A. Lezhava, Dzh. G. Monaselidze, et al., Ibid., No. 10, 451-455.

  4. 4.

    V. N. Anisimov, V. Kh. Khavinson, A. I. Mikhalski, and A. I. Yashin, Mech. Aging Dev., 122, 41-68 (2001).

    Google Scholar 

  5. 5.

    V. N. Anisimov, V. Kh. Khavinson, I. G. Popovich, and M. A. Zabezhinski, Cancer Lett., 183, 1-8 (2002).

    Google Scholar 

  6. 6.

    V. N. Anisimov, V. Kh. Khavinson, M. Provinciali, et al., Int. J. Cancer, 101, 7-10 (2002).

    Google Scholar 

  7. 7.

    L. W. Elmore and S. E. Holt, Mol. Carcinog., 28,No. 1, 1-4 (2000).

    Google Scholar 

  8. 8.

    J. Feng, W. D. Funk, S. S. Wang, et al., Science, 269,No. 5228, 1236-1241 (1995).

    Google Scholar 

  9. 9.

    E. Hiyama, K. Hiyama, T. Yokoyama, et al., Nat. Med., 1, 249-255 (1995).

    Google Scholar 

  10. 10.

    V. Kh. Khavinson, Neuroendocrinol. Lett., 23,Suppl. 3, 11-144 (2002).

    Google Scholar 

  11. 11.

    V. Khavinson, N. Goncharova, and B. Lapin, Ibid., 22, 251-254 (2001).

    Google Scholar 

  12. 12.

    M. Meyerson, C. Counter, and E. N. Eaton, Cell, 90,No. 4, 785-795 (1997).

    Google Scholar 

  13. 13.

    G. B. Morin, Ibid., 59,No. 3, 521-529 (1989).

    Google Scholar 

  14. 14.

    N. Rufer, W. Dragowska, G. Thornbury, et al., Nat. Biotechnol., 16,No. 8, 743-747 (1998).

    Google Scholar 

  15. 15.

    W. E. Wright and J. W. Shay, Ibid., 20,No. 7, 682-688 (2002).

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to V. Kh. Khavinson.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Khavinson, V.K., Bondarev, I.E. & Butyugov, A.A. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bulletin of Experimental Biology and Medicine 135, 590–592 (2003). https://doi.org/10.1023/A:1025493705728

Download citation

  • peptide
  • Epithalon
  • telomerase
  • telomeres
  • fibroblasts