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Biotechnology Letters

, Volume 25, Issue 18, pp 1549–1553 | Cite as

An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene

  • Hye Kyung Chung
  • Eun Kyong Bae
  • Hee Jung Ji
  • Jung Suk Hwang
  • Dong Woon Park
  • Jung Eun Kim
  • Hwa Jin Jung
  • Hyun Ju Choi
  • Dong Seok Lee
  • Hyun Joo Youn
Article

Abstract

Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. RT-PCR analysis confirmed the down-regulation of the Fas gene by the AVF3 treatment, supporting that the AVF3 modulated thymocyte death by suppressing the Fas gene expression.

apoptosis Artemisia Fas genomics polysaccharide 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Hye Kyung Chung
    • 1
    • 2
  • Eun Kyong Bae
    • 1
    • 2
  • Hee Jung Ji
    • 1
    • 2
  • Jung Suk Hwang
    • 1
    • 2
  • Dong Woon Park
    • 1
    • 2
  • Jung Eun Kim
    • 1
    • 2
  • Hwa Jin Jung
    • 1
    • 2
  • Hyun Ju Choi
    • 2
  • Dong Seok Lee
    • 2
  • Hyun Joo Youn
    • 1
    • 2
  1. 1.Departments of Microbiology and School of Biotechnology & Biomedical ScienceKorea
  2. 2.Department of Medical TechnologyInje UniversityGimhaeKorea

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