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Proteinases from Carica papaya Latex

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Abstract

Data on the proteinase complex from Carica papaya latex were reviewed. The properties and applications of the domestic preparation cucumazyme and known medicinal preparations based on papaya proteinases (caripazyme, lecozyme, lecopain) were compared.

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REFERENCES

  1. M. L. Fainter and O. H. Buchanan, Foreword (Papain), Ann. N. Y. Acad. Sci., 54, 147 (1951).

    Google Scholar 

  2. G. Reed, Enzymes in Food Processing, Academic Press, New York (1966).

    Google Scholar 

  3. A. N. Glazer and E. L. Smith, "Papain and other plant sulfhydryl proteolytic enzymes," in: The Enzymes, Vol. III, Hydrolysis: Peptide Bonds, P. D. Boyer, ed., Academic Press (1971), p. 501.

  4. V. V. Mosolov, Proteolytic Enzymes [in Russian], Nauka, Moscow (1971), p. 207.

    Google Scholar 

  5. R. Arnon, in: Methods in Enzymology, S. P. Colowick and N. O. Kaplan, eds., Academic Press, New York and London (1970), p. 226.

    Google Scholar 

  6. K. R. Lynn, Biochim. Biophys. Acta, 569, 193 (1979).

    Google Scholar 

  7. E. F. Redina, L. G. Mezhlumyan, T. D. Kasymova, and P. Kh. Yuldashev, Khim. Prir. Soedin., 876 (1993).

  8. E. A. Kostanova, E. V. Sokolova, and V. V. Mosolov, Prikl. Biokhim. Mikrobiol., 22, 43 (1986).

    Google Scholar 

  9. E. A. Kostanova, T. A. Valueva, V. V. Mosolov, and B. N. Golovkin, Prikl. Biokhim. Mikrobiol., 24, 795 (1988).

    Google Scholar 

  10. D. J. Buttle and A. J. Barret, Biochem. J., 223, 81 (1984).

    Google Scholar 

  11. K. Brocklehurst, R. McKee, E. Salih, and H. Smith, Biochem. J., 4, 103 (1985).

    Google Scholar 

  12. R. A. McKee and H. Smith, Phytochemistry, 25, 2283 (1986).

    Google Scholar 

  13. A. Milivoevich, Application of Carica papaya Proteolytic Enzymes (Lecozyme, Lecopain) in Broad Medical Practice [in Russian], Moscow (1978), p. 19.

  14. V. M. Lakhtin, E. A. Kotanova, and N. P. Arbatskii, Prikl. Biokhim. Mikrobiol., 31, 247 (1995).

    Google Scholar 

  15. E. L. Smith, J. R. Kimmel, D. H. Brown, and E. O. P. Thompson, J. Biol. Chem., 215, 67 (1955).

    Google Scholar 

  16. J. B. Howard and A. N. Glazer, J. Biol. Chem., 242, 5715 (1967).

    Google Scholar 

  17. V. U. Khuzhaev and S. F. Aripova, Khim. Prir. Soedin., 342 (2000).

  18. G. W. Robinson, Biochemistry, 14, 3695 (1975).

    Google Scholar 

  19. S. Zucker, D. J. Buttle, M. J. A. Nocklin, and A. J. Barrett, Biochem. Biophys. Acta, 828, 196 (1985).

    Google Scholar 

  20. R. A. McKee and H. Smith, Phytochemistry, 25, 2283 (1986).

    Google Scholar 

  21. P. W. Goodenough and A. J. Owen, Phytochemistry, 26, 75 (1987).

    Google Scholar 

  22. D. V. Buttle, A. A. Kembhavi, S. L. Sharp, R. E. Shute, D. H. Rich, and J. Barrett, Biochem. J., 261, 469 (1989).

    Google Scholar 

  23. Intl. Pat. No. 90/13561 (1990); Izobret. Stran Mira, 41, No. 16, 41 (1991).

  24. D. J. Buttle and A. J. Barrett, Biochemistry, 223, 81 (1984).

    Google Scholar 

  25. L. G. Dudchenko and V. V. Krivenko, Food and Medicinal Plants [in Russian], Naukova Dumka, Kiev (1988), p. 288.

    Google Scholar 

  26. M. Ebata and K. T. Jasukoba, J. Biol. Chem., 237, 1086 (1962).

    Google Scholar 

  27. E. D. Kaverzneva, Prikl. Biokhim. Mikrobiol., 7, 225 (1971).

    Google Scholar 

  28. A. S. Labinskaya, Microbiology with Microbiology Research Techniques [in Russian], Meditsina, Moscow (1978), p. 156.

    Google Scholar 

  29. A. P. Tofilo and M. P. Antonov, Lab. Delo, 27 (1988).

  30. D. G. Chanturiya, G. S. Erkomaishvili, and M. V. Vandachkoriya, in: Materials of the 2nd Convention of Georgian Pharmaceuticals, Tbilisi (1987), 214; Ref. Zh. Khim., No. 11, O435 (1988).

  31. H. Zineweaver and S. Schwimmer, Enzymologia, 10, 81 (1941).

    Google Scholar 

  32. A. V. Maksimenko, L. A. Nadirashvili, V. V. Abramova, G. S. Erkomaishvili, and V. P. Torchilin, Biotekhnologiya, 56 (1990).

  33. L. A. Sluyterman, Biochem. Biophys. Acta, 139, 418 (1967).

    Google Scholar 

  34. N. Rasalakshmi and P. V. Sundaram, Protein Eng., 8, 1039 (1995).

    Google Scholar 

  35. D. J. Battle, Biol. Chem. Hoope-Seyler, 371, 1083 (1990).

    Google Scholar 

  36. A. M. Gonchar, A. S. Kogan, and R. I. Salganik, Wound Process and Immobilized Proteolytic Enzymes [in Russian], Novosibirsk (1986).

  37. V. K. Gostishchev, A. N. Afanas'ev, and A. M. Khokhlov, Khirurgiya, 40 (1999).

  38. Zh. A. Narchaev, Kh. K. Abdurakhmanov, R. K. Rakhmanov, and L. G. Mezhlumyan, Khim. Prir. Soedin., 149 (1998).

  39. Kh. K. Abdurakhmanov, Zh. A. Narchaev, R. K. Rakhmanov, and T. D. Kasymova, Khim. Prir. Soedin., 151 (1998).

  40. B. N. Gazetov and A. P. Kalinin, Surgical Diseases of Sugar Diabetics [in Russian], Meditsina, Moscow (1990).

    Google Scholar 

  41. Zh. A. Narchaev, R. K. Rakhmanov, Kh. K. Abdurakhmanov, and P. Kh. Yuldashev, Khir. Uzb., 93 (2000).

  42. N. M. Normatova, Kh. M. Kamilov, and P. Kh. Yuldashev, Khim. Prir. Soedin., 146 (1998).

  43. M. U. Isaev, G. Abdul, V. Yu. Chirko, L. M. Begimbekova, M. Yu. Chirko, and B. A. Myrzaliev, Papain, a proteolytic Enzyme of Plant Origin [in Russian], Uzbekiston, Tashkent (2000).

    Google Scholar 

  44. Kh. U. Aliev, I. K. Azizov, M. R. Rakhimov, and N. A. Musaeva, in: Abstracts of the International Conference on Applied Aspects of Biotechnology, Tashkent (2002), p. 66.

  45. L. G. Mezhlumyan, A.N. Kim, and P. Kh. Yuldashev, in: Abstracts of the International Symposium on the Chemisttry of Natural Compounds, Tashkent (2003), p. 145.

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Mezhlumyan, L.G., Kasymova, T.D. & Yuldashev, P.K. Proteinases from Carica papaya Latex. Chemistry of Natural Compounds 39, 223–228 (2003). https://doi.org/10.1023/A:1025466030937

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