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Preparation of Biologically Transformed Raw Material of Woolly Foxglove (Digitalis lanata Ehrh.) and Isolation of Digoxin Therefrom

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Abstract

A biotechnological approach is proposed for anaerobic conservation of aerial parts of woolly foxglove, followed by air–sun drying of the biologically transformed raw material. During the conservation, primary glycosides of foxglove undergo complete conversion into secondary glycosides, with no further transformations. A simple method is described for preparing an enriched glycoside fraction from the transformed raw material (yield, 3.6%) and for isolating highly purified digoxin from this fraction (yield, 0.06% of the starting raw material); other secondary glycosides can also be isolated.

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Authors and Affiliations

  1. Russian Academy of Agricultural Sciences, All-Russia Institute of Medicinal and Aromatic Plants, Moscow, 117216, Russia

    V. S. Fonin & A. Ya. Khorlin

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  1. V. S. Fonin
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  2. A. Ya. Khorlin
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Fonin, V.S., Khorlin, A.Y. Preparation of Biologically Transformed Raw Material of Woolly Foxglove (Digitalis lanata Ehrh.) and Isolation of Digoxin Therefrom. Applied Biochemistry and Microbiology 39, 519–523 (2003). https://doi.org/10.1023/A:1025461005863

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