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Synthesis of Thiazino- and Thiazoloquinazolinones by Cyclization of S-(2-Propenyl) Derivatives of 2-Thioxo-2,3-dihydro-4(1H)-quinazolinone

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Abstract

Interaction of potassium salts of quinazolin-2-thiol-4-one with γ-substituted allyl halides gave thiazoloquinazolinones with linear or angular structures depending on the structure of the carbonyl radical. S-Allyl substituted quinazolin-2-thiol-4-one reacted with halogens to give iminium salts of thiazinoquinazolinone with an angular structure. The conversion of these salts to the corresponding bases and thiazoloquinazolinones has been studied.

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Authors and Affiliations

  1. Uzhgorod State University, Uzhgorod, 88000, Ukraine

    V. V. Orysyk, A. A. Dobosh & S. M. Khripak

  2. National Academy of Sciences of Ukraine, Institute of Organic Chemistry, Kiev, 02094, Ukraine

    Yu. L. Zborovskii & V. I. Staninets

Authors
  1. V. V. Orysyk
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  2. Yu. L. Zborovskii
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  3. V. I. Staninets
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  4. A. A. Dobosh
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  5. S. M. Khripak
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Orysyk, V.V., Zborovskii, Y.L., Staninets, V.I. et al. Synthesis of Thiazino- and Thiazoloquinazolinones by Cyclization of S-(2-Propenyl) Derivatives of 2-Thioxo-2,3-dihydro-4(1H)-quinazolinone. Chemistry of Heterocyclic Compounds 39, 640–644 (2003). https://doi.org/10.1023/A:1025154317771

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  • DOI: https://doi.org/10.1023/A:1025154317771

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