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Gas Chromatographic Determination of Diacetylmorphine with Mass Spectrometric Detection

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Abstract

The possibility of determining diacetylmorphine traces in various matrices by gas chromatography with mass spectrometric detection is demonstrated. Diacetylmorphine can be reliably determined by gas chromatography–mass spectrometry in the range 0.02–7.5 μg/mL. A procedure is developed for the quantitative determination of diacetylmorphine and its concomitants, including acetylated opioid derivatives, in forensic samples. The detection limit for diacetylmorphine without preconcentration is 0.01 μg/mL. The detection limit in the selective-ion monitoring mode with preconcentration is 1 × 10–4 μg/mL.

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Authors and Affiliations

  1. Forensic Examination Center, Ministry of Internal Affairs of Tatarstan, ul. Dzerzhinskogo 19, 420503, Kazan, Tatarstan, Russia

    I. M. Fitsev, V. K. Blokhin & P. G. Teslenko

  2. Department of Chemistry, Kazan State University, ul. Kremlevskaya 18, 420008, Kazan, Tatarstan, Russia

    G. K. Budnikov

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  1. I. M. Fitsev
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  2. G. K. Budnikov
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  3. V. K. Blokhin
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  4. P. G. Teslenko
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Fitsev, I.M., Budnikov, G.K., Blokhin, V.K. et al. Gas Chromatographic Determination of Diacetylmorphine with Mass Spectrometric Detection. Journal of Analytical Chemistry 58, 755–761 (2003). https://doi.org/10.1023/A:1025087627804

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