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HPLC Determination of Ritodrine Hydrochloride in Pharmaceutical Formulations

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Abstract

A simple, rapid, and accurate HPLC method is described for the determination of ritodrine hydrochloride (RTH) in both pure form and pharmaceutical formulations. A Hypersil Shendon ODS column with a mobile phase of dibasic phosphate buffer and acetonitrile (75 : 25) and isoxsuprine hydrochloride were used as an internal standard. The flow rate was 1 mL min–1 and the effluent was monitored at 270 nm pH 4.0. The calibration graph is linear in the range 2–30 μg mL–1. The proposed HPLC method has been successfully employed for the determination of RTH in Yutopar tablets and injection solutions.

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Authors and Affiliations

  1. Department of Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, Karnataka, India

    H. D. Revanasiddappa

  2. Department of Chemistry, P.E.S. College of Engineering, Mandya, 571401, India

    B. Manju

Authors
  1. H. D. Revanasiddappa
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  2. B. Manju
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Revanasiddappa, H.D., Manju, B. HPLC Determination of Ritodrine Hydrochloride in Pharmaceutical Formulations. Journal of Analytical Chemistry 58, 775–777 (2003). https://doi.org/10.1023/A:1025043812783

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  • DOI: https://doi.org/10.1023/A:1025043812783

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