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DSLET and ACTH4-10 Increase Mitotic Activity of Hepatocytes and Suppress Antibody Production

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Abstract

The mitotic index of hepatocytes remained unchanged after 10 intraperitoneal injections of DSLET and ACTH4-10 in doses of 0.5, 1.5, and 5 μg/kg, but increased after injection of these substances in doses of 50 and 150 μg/kg. DSLET in doses of 5, 50, and 150 μg/kg decreased the number of antibody-producing cells in the spleen. ACTH4-10 possessed immunosuppressive activity not only in these doses, but also in a dose of 1.5 μg/kg. As differentiated from mitotic activity of hepatocytes, the degree of immunosuppression increased with increasing the dose of test peptides.

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Authors and Affiliations

  1. Department of Pathophysiology, Kursk State Medical University, Russia

    M. Yu. Smakhtin, A. I. Konoplya, L. A. Sever'yanova & I. A. Shveinov

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  1. M. Yu. Smakhtin
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  2. A. I. Konoplya
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  3. L. A. Sever'yanova
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  4. I. A. Shveinov
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Correspondence to M. Yu. Smakhtin.

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Smakhtin, M.Y., Konoplya, A.I., Sever'yanova, L.A. et al. DSLET and ACTH4-10 Increase Mitotic Activity of Hepatocytes and Suppress Antibody Production. Bulletin of Experimental Biology and Medicine 135, 428–429 (2003). https://doi.org/10.1023/A:1024998805553

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