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Participation of Endogenous Opioids in Pathogenesis of Early Neuroendocrine Manifestations of Prenatal Stress Syndrome

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Abstract

We studied sex dimorphism in the content of norepinephrine and activity of enzymes involved in testosterone metabolism in the preoptic hypothalamic area of 10-day-old rats. Prenatal stress eliminated sex-related differences in these indices. These disturbances were absent in rats subjected to prenatal stress under conditions of opioid receptor blockade with naltrexone. These data attests to the important role of opioids in the pathogenesis of prenatal stress syndrome.

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Authors and Affiliations

  1. Ukrainian Academy of Medical Sciences, V. P. Komissarenko Institute of Endocrinology and Metabolism, Kiev

    A. G. Reznikov, N. D. Nosenko & L. V. Tarasenko

Authors
  1. A. G. Reznikov
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  2. N. D. Nosenko
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  3. L. V. Tarasenko
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Correspondence to A. G. Reznikov.

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Reznikov, A.G., Nosenko, N.D. & Tarasenko, L.V. Participation of Endogenous Opioids in Pathogenesis of Early Neuroendocrine Manifestations of Prenatal Stress Syndrome. Bulletin of Experimental Biology and Medicine 135, 421–423 (2003). https://doi.org/10.1023/A:1024994704644

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  • DOI: https://doi.org/10.1023/A:1024994704644

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