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Expression of Flt-1 and Flk-1 Receptors for Vascular Endothelial Growth Factor on Tumor Cells as a New Prognostic Criterion for Locally Advanced Breast Cancer

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Abstract

We studied expression of Flt-1 and Flk-1 receptors on tumor cells obtained from 83 patients with locally advanced breast cancer after neoadjuvant chemotherapy. The mean period of observations was 32.3 months. The median recurrence-free survival periods for Flt-1+ and Flt-1- patients were 55 and 32 months, respectively (p=0.0064). The overall survival periods for Flt-1- and Flt-1+ patients were 45 and 67.6 months, respectively (p=0.014). The mean recurrence-free survival periods for Flk-1+ and Flk-1- patients were 40.8 and 60.9 months, respectively (p=0.035). Expression of VEGF had no prognostic value. Our results show that overexpression of Flk-1 on breast cancer cells in patients receiving neoadjuvant chemotherapy is associated with a poor prognosis. By contrast, overexpression of Flt-1 improves survival.

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Authors and Affiliations

  1. N. N. Blokhin Russian Research Center for Oncology, Russian Academy of Medical Sciences, Moscow

    L. G. Zhukova, N. V. Zhukov & M. R. Lichinitser

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  1. L. G. Zhukova
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  2. N. V. Zhukov
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  3. M. R. Lichinitser
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Zhukova, L.G., Zhukov, N.V. & Lichinitser, M.R. Expression of Flt-1 and Flk-1 Receptors for Vascular Endothelial Growth Factor on Tumor Cells as a New Prognostic Criterion for Locally Advanced Breast Cancer. Bulletin of Experimental Biology and Medicine 135, 478–481 (2003). https://doi.org/10.1023/A:1024975627843

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