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Stimulation of Mouse Resistance to Bacterial Infection with Muramyl Dipeptide Glycoside

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Abstract

We studied the capacity of 9 new muramyl dipeptide glycosides to stimulate mouse resistance to experimental sepsis induced by intraperitoneal injection of salmonella typhimurium culture. Preventive intraperitoneal injections of muramyl dipeptide β-glycosides better improved survival of infected animals compared to the original (unmodified) muramyl dipeptide and muramyl dipeptide α-glycosides. The most effective drug muramyl dipeptide β-heptylglycoside injected during sepsis development also reduced animal mortality, decreased bacterial contamination of the viscera, and increased phagocytic activity of peritoneal macrophages in infected animals.

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Authors and Affiliations

  1. Laboratory of Cellular Immunopathology and Biotechnology, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow

    O. V. Kalyuzhin, N. G. Kalina, A. F. Bashtanenko, M. V. Shkalev, F. N. Kuzovlev & V. V. Kalyuzhin

  2. Laboratory of Non-Parenteral methods of Immunization, I. I. Mechnikov Central Institute of Vaccines and Sera, Russian Academy of Medical Sciences, Moscow

    O. V. Kalyuzhin, N. G. Kalina, A. F. Bashtanenko, M. V. Shkalev, F. N. Kuzovlev & V. V. Kalyuzhin

Authors
  1. O. V. Kalyuzhin
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  2. N. G. Kalina
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  3. A. F. Bashtanenko
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  4. M. V. Shkalev
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  5. F. N. Kuzovlev
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  6. V. V. Kalyuzhin
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Correspondence to O. V. Kalyuzhin.

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Kalyuzhin, O.V., Kalina, N.G., Bashtanenko, A.F. et al. Stimulation of Mouse Resistance to Bacterial Infection with Muramyl Dipeptide Glycoside. Bulletin of Experimental Biology and Medicine 135, 452–455 (2003). https://doi.org/10.1023/A:1024963325117

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  • DOI: https://doi.org/10.1023/A:1024963325117

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