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Ketamine-Induced Rotational Asymmetry in Evaluation of Motor Disturbances in Rats with Middle Cerebral Artery Occlusion

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Abstract

Intraperitoneal injection of ketamine in subanesthetic doses to Wistar rats with unilateral occlusion of the middle cerebral artery caused ipsilateral rotation (2-10 rpm), which was recorded in an automatic rotameter. The optimal dose of ketamine was 50 mg/kg. The animals were examined in an automatic rotameter for 40 min. Motor asymmetry persisted for no less than 2 months after surgery. According to the neurological test (Menzies scale) motor asymmetry in animals with focal brain ischemia persisted for no more than 30 days. The degree of ketamine-induced motor asymmetry in intact rats was 0.10±0.03 rpm.

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Authors and Affiliations

  1. V. P. Serbskii State Research Center for Social and Forensic Psychiatry, Moscow

    S. V. Lebedev, S. V. Petrov, D. V. Blinov, I. P. Lazarenko & V. P. Chekhonin

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  1. S. V. Lebedev
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  2. S. V. Petrov
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  3. D. V. Blinov
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  4. I. P. Lazarenko
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  5. V. P. Chekhonin
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Correspondence to S. V. Lebedev.

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Lebedev, S.V., Petrov, S.V., Blinov, D.V. et al. Ketamine-Induced Rotational Asymmetry in Evaluation of Motor Disturbances in Rats with Middle Cerebral Artery Occlusion. Bulletin of Experimental Biology and Medicine 135, 424–427 (2003). https://doi.org/10.1023/A:1024946821482

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