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Respiratory Activity of Bulbospinal Preparations from Newborn Rats Subjected to Periodic Hypercapnia in the Prenatal Period

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Abstract

Periodic exposure of pregnant rats to hypercapnia (10% CO2) delayed the development of mechanisms underlying respiratory rhythmogenesis in newborn animals during the early postnatal period. In vitro studies showed that rhythmic activity of the respiratory center in newborn rats (days 0-3) was 2-3-fold lower than that in intact preparations. Age-related changes of respiratory activity were absent, while the reactions of the respiratory center to CO2 were suppressed compared to the control.

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Authors and Affiliations

  1. Samara State Medical University, Russia

    I. V. Miroshnichenko & V. F. Pyatin

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  1. I. V. Miroshnichenko
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  2. V. F. Pyatin
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Correspondence to I. V. Miroshnichenko.

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Miroshnichenko, I.V., Pyatin, V.F. Respiratory Activity of Bulbospinal Preparations from Newborn Rats Subjected to Periodic Hypercapnia in the Prenatal Period. Bulletin of Experimental Biology and Medicine 135, 416–420 (2003). https://doi.org/10.1023/A:1024942720574

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