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A Synthesis of Dolichyl Phosphorofluoridate

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Abstract

An improved method for the synthesis of dolichyl H-phosphonate was developed using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one (salicyl chlorophosphite) as a reagent. Dolichyl phosphorofluoridate was for the first time synthesized from dolichyl H-phosphonate by its treatment with chlorotrimethylsilane,followed by oxidation with iodine in the presence of fluoride in pyridine.

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Authors and Affiliations

  1. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 119991, Russia

    O. V. Sizova, S. D. Mal'tsev & V. N. Shibaev

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  1. O. V. Sizova
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  2. S. D. Mal'tsev
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  3. V. N. Shibaev
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Sizova, O.V., Mal'tsev, S.D. & Shibaev, V.N. A Synthesis of Dolichyl Phosphorofluoridate. Russian Journal of Bioorganic Chemistry 29, 387–389 (2003). https://doi.org/10.1023/A:1024909519917

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  • DOI: https://doi.org/10.1023/A:1024909519917

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