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Loading amplification of radiation grafted polymers (crowns and lanterns) and their application in the solid-phase synthesis of hydantoin libraries

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Abstract

Solid-phase dendrimer chemistry using a symmetrical 1→3C-branched isocyanate monomer was used to prepareradiation-grafted polymers with enhanced loading. Afterevaluation of the physical and chemical properties of thesenew high-loading supports, they were tested in the multipleparallel synthesis of hydantoins.

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Authors and Affiliations

  1. Department of Chemistry, University of Southampton, Southampton, Hampshire, SO17 1BJ, U.K.

    Sylvain Lebreton

  2. AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, U.K.

    Nicholas Newcombe

  3. Department of Chemistry, University of Southampton, Southampton, Hampshire, SO17 1BJ, U.K.

    Mark Bradley

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  1. Sylvain Lebreton
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  2. Nicholas Newcombe
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  3. Mark Bradley
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Correspondence to Mark Bradley.

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Lebreton, S., Newcombe, N. & Bradley, M. Loading amplification of radiation grafted polymers (crowns and lanterns) and their application in the solid-phase synthesis of hydantoin libraries. Mol Divers 6, 19–26 (2003). https://doi.org/10.1023/A:1024867013184

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