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Approaches to intramolecular sialylation. 1. Synthesis of pseudodisaccharide Neu5Ac-(1-2)-Gal with ester-linked monosaccharide residues

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Abstract

An efficient approach was developed for ester-linking the sterically hindered carboxy group of N-acetylneuraminic acid with the secondary hydroxy group at C(2) of galactose. Putative precursors of the glycosidically linked disaccharide Neu5Ac-(2-3)-Gal were prepared.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    L. O. Kononov & D. A. Volodin

  2. Organic Chemistry 2, Chemical Center, Lund University, P.O. Box 142, S-221 00, Lund, Sweden

    G. Magnusson

Authors
  1. L. O. Kononov
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  2. D. A. Volodin
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  3. G. Magnusson
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Kononov, L.O., Volodin, D.A. & Magnusson, G. Approaches to intramolecular sialylation. 1. Synthesis of pseudodisaccharide Neu5Ac-(1-2)-Gal with ester-linked monosaccharide residues. Russian Chemical Bulletin 52, 1434–1441 (2003). https://doi.org/10.1023/A:1024803900642

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  • DOI: https://doi.org/10.1023/A:1024803900642

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