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Association between coronary endothelial dysfunction and local inflammation of atherosclerotic coronary arteries

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Abstract

We have examined a possibility whether or not severity and extent of coronary atherosclerosis may associate with degree of local inflammation in relation to endothelial dysfunction as is indicated by reduced NO formation. Blood samples were obtained from aortic root (Ao) and coronary sinus (CS) of 39 patients who underwent coronary angiography. Plasma NOx levels (nitrite + nitrate, stable NO end-products) were evaluated by HPLC-Griess system, and markers of inflammation, C-reactive protein (CRP) and serum amyloid A protein (SAA), were measured by Latex Turbidimetric Immunoassay. To evaluate the changes of these substances through coronary circulation, the percentage changes of respective markers [(CS – Ao) × 100/Ao] were calculated. The extent and severity of atherosclerosis of left coronary arteries were evaluated with Gensini Score (GS). The GS correlated with the percentage changes of NOx (r = −0.35, p < 0.05) and that of SAA (r = 0.43, p < 0.05) across coronary circulation, but not with changes in CRP. Moreover, the percentage changes of NOx correlated with that of SAA (r = −0.36, p < 0.05). These results indicated that severity and extent of coronary atherosclerosis related to degree of local inflammation which has a possible association with coronary endothelial dysfunction.

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Authors and Affiliations

  1. Divison of Cardiology, Shinrakuen Hospital, Niigata, 950-2087, Japan

    Taku Matsubara

  2. Department of Pharmacology, Kanazawa Medical University, Ishikawa, 920-0293, Japan

    Takaharu Ishibashi & Matomo Nishio

  3. First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8510, Japan

    Tomoyuki Hori, Kazuyuki Ozaki, Tohru Mezaki, Keiichi Tsuchida, Akimitsu Nasuno, Kaname Kubota, Takayuki Tanaka & Yoshifusa Aizawa

  4. First Department of Laboratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8510, Japan

    Takashi Miida

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  1. Taku Matsubara
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  2. Takaharu Ishibashi
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  11. Yoshifusa Aizawa
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Matsubara, T., Ishibashi, T., Hori, T. et al. Association between coronary endothelial dysfunction and local inflammation of atherosclerotic coronary arteries. Mol Cell Biochem 249, 67–73 (2003). https://doi.org/10.1023/A:1024778421491

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  • DOI: https://doi.org/10.1023/A:1024778421491

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