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Formulation of a freeze-dried kit for 188Re-MAG3 and its quality control

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Abstract

The synthesis of 188Re-MAG3 is described using 188Re, which was obtained from the alumina based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-MAG3 on reducing agent concentration, Bz-MAG3 concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-MAG3 was 98%. TLC and HPLC techniques were employed to monitor the different species formed. Biodistribution study of 188Re-MAG3 was carried out in rats and compared with behavior of 99mTc-MAG3.

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References

  1. A. R. Fritzberg, S. Kasina, D. Eshima, D. L. Johnson, J. Nucl. Med., 27 (1986) 111.

    Google Scholar 

  2. S. Guhlke, A. Schaffland, P. O. Zamora, J. Sartor, D. Diekmann, H. Bender, F. F. Knapp Jr., H. J. Biersack, Nucl. Med. Biol., 25 (1998) 621.

    Google Scholar 

  3. U. O. Haefeli, W. K. Roberts, G. J. Pauer, S. K. Kraeft, R. M. Maklis, Appl. Radiation Isotopes, 54 (2001) 869.

    Google Scholar 

  4. F. F. Knapp Jr., S. Mirzadeh, Eur. J. Nucl. Med., 21 (1994) 1151.

    Google Scholar 

  5. T. A. Mabin, D. R. Holmes, J. C. Smith, Circ. Res., 71 (1985) 754.

    Google Scholar 

  6. J. J. Popma, R. M. Califf, E. J. Topol, Circulation, 84 (1991) 1426.

    Google Scholar 

  7. F. F. Knapp Jr., S. Guhlke, A. L. Beets, W. Y. Lin, M. Stabin, H. Amols, J. Weinberger, Cardiovasc. Radiat. Med., 1 (1999) 86.

    Google Scholar 

  8. J. Weinberger, F. F. Knapp Jr., Use of liquid-filled balloons for coronary irradiation, in: Vascular Brachytherapy, 2nd ed., R. Waksman (Ed.), Futura, Armonk, New York, p. 521.

  9. B. T. Hsieh, J. F. Hsieh, S. C. Tsai, W. Y. Lin, H. T. Huang, G. Ting, S. J. Wang, Nucl. Med. Biol., 26 (1999) 967.

    Google Scholar 

  10. T. Das, S. Banerjee, G. Samuel, K. Kothary, P. R. Unni, H. D. Sarma, N. Ramamoorthy, M. R. A. Pillai, Nucl. Med. Biol., 27 (2000) 189.

    Google Scholar 

  11. G. Bormans, B. Cleynhens, P. Adriaens, H. Vanbilloen, M. De Roo, A. Verbruggen, Nucl. Med. Biol., 22 (1995) 339.

    Google Scholar 

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Authors and Affiliations

  1. Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Box, Nilore, Islamabad, Pakistan

    S. Pervez & A. Mushtaq

  2. Bahauddin Zakariya University, Multan, Pakistan

    M. Arif

Authors
  1. S. Pervez
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  2. A. Mushtaq
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  3. M. Arif
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Pervez, S., Mushtaq, A. & Arif, M. Formulation of a freeze-dried kit for 188Re-MAG3 and its quality control. Journal of Radioanalytical and Nuclear Chemistry 257, 421–424 (2003). https://doi.org/10.1023/A:1024764703623

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  • DOI: https://doi.org/10.1023/A:1024764703623

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