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Synthesis of radioiodinated labeled peptides

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Abstract

This report covers optimization of radioiodination of peptides by both a direct method in which a constituent tyrosine residue is labeled and indirect method by using an iodinated derivative (SIB) of N succinimidyl 3-(tri-n-butylstannyl) benzoate (ATE) as the intermediate. Radioiodination of IgG and FMLF were performed by direct method using Chloramine-T as an oxidant but since Formyl-Methyl-Leucyl-Phenylalanine, FMLF, does not lend itself for direct radioiodination we performed labeling of FMLF by indirect method via radioiodined SIB at different pH.

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Authors and Affiliations

  1. Cyclotron Department, Research Center for Agriculture & Medicine, P.O. Box: 31585, 4395, Karaj, Iran

    M. Matloobi & H. Rafii

  2. Faculty of Pharmacy, Tehran University, Tehran, Iran

    D. Beigi, A. Khalaj & M. Kamali-Dehghan

Authors
  1. M. Matloobi
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  2. H. Rafii
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  3. D. Beigi
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  4. A. Khalaj
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  5. M. Kamali-Dehghan
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Matloobi, M., Rafii, H., Beigi, D. et al. Synthesis of radioiodinated labeled peptides. Journal of Radioanalytical and Nuclear Chemistry 257, 71–73 (2003). https://doi.org/10.1023/A:1024741209133

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  • DOI: https://doi.org/10.1023/A:1024741209133

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