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Interaction of Palladium(II) Acido Complexes with DNA

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Abstract

Interaction of K2[PdCl4] (I) and (C5H12NO)2[PdCl4] (II) with DNA in vitro is studied. No fragmentation of DNA occurs under the action of II. The interstrand cross-links are formed due to the formation of complexes with purine and pyrimidine bases; no interaction with DNA phosphates is observed. The cation does not play an essential role in the formation of cross-links.

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, 119991, Russia

    A. G. Tikhomirov, N. A. Ivanova, O. S. Erofeeva, L. B. Gorbacheva & I. A. Efimenko

  2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia

    A. G. Tikhomirov, N. A. Ivanova, O. S. Erofeeva, L. B. Gorbacheva & I. A. Efimenko

Authors
  1. A. G. Tikhomirov
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  2. N. A. Ivanova
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  3. O. S. Erofeeva
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  4. L. B. Gorbacheva
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  5. I. A. Efimenko
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Tikhomirov, A.G., Ivanova, N.A., Erofeeva, O.S. et al. Interaction of Palladium(II) Acido Complexes with DNA. Russian Journal of Coordination Chemistry 29, 489–493 (2003). https://doi.org/10.1023/A:1024731014000

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  • DOI: https://doi.org/10.1023/A:1024731014000

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