Abstract
Bone seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of 153Sm and 166Ho are receiving considerable attention for therapeutic treatment of bone metastases. Rhenium-188 has both beta-particle emissions for a therapeutic effect and gamma-emissions for imaging and it is available from an in-house generator system similar to the current 99mTc generator, which makes it convenient for clinical use. The preparation of 188Re-EDTMP is described using 188Re, which was obtained from the alumina-based 188W/188Re generator. Dependence of the radiolabeling yield of 188Re-EDTMP on reducing agent concentration, EDTMP concentration, incubation time, pH and addition of carrier was examined. In the case of optimum conditions, the radiolabeling yields of 188Re-EDTMP were ~98% for carrier-free as well as carrier-added 188Re. The addition of ascorbic acid plays an important role in the stability of carrier-free as well as carrier-added 188Re-EDTMP preparations. The biodistribution of carrier-free and carrier-added 188Re-EDTMP compounds in rats was also studied. The results show that 188Re (carrier-added)-EDTMP is a potential bone pain palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft tissue absorption.
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References
C. A. Hoefnagel, Eur. J. Nucl. Med., 18 (1991) 408.
R. A. Holmes, Semin. Nucl. Med., 22 (1992) 41.
G. M. Blake, M. A. Zivanovic, A. J. McEwan, V. B. Batty, D. M. Ackery, Eur. J. Nucl. Med., 13 (1987) 41.
M. A. Davis, M. Chinol, J. Nucl. Med., 30 (1989) 1047.
M. Eisenhut, J. Nucl. Med., 25 (1984) 1356.
A. Mushtaq, M. Jawaid, M. M. Ishfaq, Nucl. Sci. J., 34 (1997) 196.
W. K. A. Louw, I. C. Dormehl, A. J. van Rensburg, N. Hugo, A. S. Alberts, O. E. Forsyth, G. Beverley, M. A. Sweetlove, J. Marais, M. G. LÖtter, A. van Aswegen, Nucl. Med. Biol., 23 (1996) 935.
A. R. Ketring, Nucl. Med. Biol., 14 (1987) 223.
W. Y. Lin, J. F. Hsieh, C. P. Lin, B. T. Hsieh, G. Ting, S. J. Wang, F. F. Knapp Jr., Nucl. Med. Biol., 26 (1999) 455.
A. Ando, I. Ando, N. Tonami, S. Kinuya, K. Kazuma, A. Kataiwa, M. Nakagawa, N. Fujita, Nucl. Med. Commun., 19 (1998) 587.
E. J. Hall, Radiobiology for the Radiologists, Harper &; Row, Phildelphia, Penn., 1978, p. 145.
H. Kamioki, S. Mirzadeh, R. M. Lambrecht, F. F. Knapp Jr., E. Dadachova, Radiochim. Acta, 65 (1994) 39.
E. Dadachova, J. Chapman, Nucl. Med. Commun., 19 (1998) 137.
A. Mushtaq, Nucl. Med. Biol., 25 (1998) 313.
F. F. (Rs), Knapp Jr., S. Mirzadeh, A. L. Beets, M. O Doherty, P. J. Blower, E. S. Verdera, J. S. Gaudiano, J. Kropp, J. Guhlke, H. Palmedo, H. J. Biersack, Appl. Radiation Isotopes, 49 (1998) 309.
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Pervez, S., Mushtaq, A., Arif, N. et al. 188Rhenium-EDTMP: A potential therapeutic bone agent. Journal of Radioanalytical and Nuclear Chemistry 257, 417–420 (2003). https://doi.org/10.1023/A:1024712719553
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DOI: https://doi.org/10.1023/A:1024712719553