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Vascular responses to endovascular irradiation of 188Re in the rabbit model after angioplasty

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Abstract

The effects on vascular restenosis of intravascular radiation delivery from 188Rhenium (Re)-perrhenate liquid-filled balloon through beta-particle radiation are controversial. To determine the effect of beta-radiation on vascular injury in hypercholesterolemic rabbits, thirty rabbits fed with a high cholesterol diet were enrolled into this study. All the rabbits underwent percutaneous transluminal balloon overstretch over left iliac artery. After balloon overstretch, the catheter was withdrawn and immediately followed by irradiation using low dose 188Re solution (10 Gray) in the vascular wall 0.5 mm distal to intimal surface. After 2 and 6 weeks, arteries were harvested for histological and immunological analysis. This rabbit study suggest that endovascular 188Re low dose irradiation at the non-injury segment of iliac artery may enhance intima hyperplasia and smooth muscle cell proliferation.

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Authors and Affiliations

  1. Institute of Nuclear Energy Research, Taiwan

    Wen-Jin Cherng & Bor-Tsung Hsieh

  2. Chang-Gung Memorial Hospital, Taiwan

    Ming-Jui Hung & K. Y. Cheng

  3. Cardiology Section, Department of Medicine, Department of Nuclear Medicine, Chang-Gung Memorial Hospital, Taiwan

    Tsu-Tsen Yen

  4. Department of Pathology, Chang-Gung Memorial Hospital, Taiwan

    Ning Lee

Authors
  1. Wen-Jin Cherng
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  2. Bor-Tsung Hsieh
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  3. Chao-Hung Wang
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  4. Ming-Jui Hung
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Cherng, WJ., Hsieh, BT., Wang, CH. et al. Vascular responses to endovascular irradiation of 188Re in the rabbit model after angioplasty. Journal of Radioanalytical and Nuclear Chemistry 257, 255–260 (2003). https://doi.org/10.1023/A:1024711224580

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