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Effect of Glyprolines on Norepinephrine Tone of Isolated Rat Aortic Rings

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Abstract

Glyprolines, short proline-containing peptides (Pro-Gly-Pro, Pro-Gly, and Gly-Pro) in concentrations of 10-8-10-4 M decreased norepinephrine tone of the isolated rat aortic rings. The vasodilatory effect of Pro-Gly-Pro and Pro-Gly was associated with NO release from endotheliocytes, while Gly-Pro directly affected vascular smooth muscle cells.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia

    Z. V. Bakaeva, K. E. Badmaeva, I. Yu. Sergeev & G. E. Samonina

Authors
  1. Z. V. Bakaeva
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  2. K. E. Badmaeva
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  3. I. Yu. Sergeev
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  4. G. E. Samonina
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Correspondence to G. E. Samonina.

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Bakaeva, Z.V., Badmaeva, K.E., Sergeev, I.Y. et al. Effect of Glyprolines on Norepinephrine Tone of Isolated Rat Aortic Rings. Bulletin of Experimental Biology and Medicine 135, 334–336 (2003). https://doi.org/10.1023/A:1024696327745

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