Abstract
Hepatitis C virus and hepatitis D virus have been shown to suppress HBsAg synthesis. Thus it is possible that HDV infection occurs despite the lack of detectable HBsAg. The aim of our study was to (a) determine the prevalence of HDV infection in patients with chronic hepatitis C (b) compare it with the prevalence of HDV infection in HBsAg positive patients with hepatitis B. The study group consisted of 51 chronic hepatitis C patients, 30 HIV infected drug addicts (27 of them were also positive for anti-HCV) and 102 hepatitis B patients. The participants were tested for anti-HDV, anti-HCV and HBsAg. All anti-HCV positive patients were negative for anti-HDV. Four individuals with anti-HDV belonged to hepatitis B group and constituted 3.9% of all HBsAg positive subjects. We conclude that (a) there is currently no evidence of HDV infection among HCV infected patients in our region (b) hepatitis delta infection is rare in north-eastern Poland.
References
Rizzetto M, Verme G. Delta hepatitis - present status. J Hepatol 1985; 1: 187–193.
Nicholson KG. Hepatitis delta infections. Br Med J 1985; 190: 1370–1371.
Lee DS, Huh K, Lee EH, Lee DH, Hong KS, Sung YC. HCV and HBV coexist in HBsAg-negative patients with HCV viraemia: Possibility of coinfection in those patients must be considered in HBV-high endemic area. J Gastroenterol Hepatol 1997; 12: 855–861.
Lopez Morante A, De La Cruz F, Rodriguez C, Echevarria S, Rodriguez GM, Pons-Romero F. Hepatitis B virus replication in hepatitis B and D coinfection. Liver 1989; 9: 65–70.
Cacciola I, Pollicino T, Squadrito G, Cerenzia G, Orlando ME, Raimondo G. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N Engl J Med 1999; 341: 22–26.
Scheuer PJ. Classification of chronic viral hepatitis: A need for reassessment. J Hepatol 1991; 13: 372–374.
Sakugawa H, Nakasone H, Kawakami Y, et al. Determination of hepatitis delta virus (HDV)-RNA in asymptomatic cases of HDV infection. Am J Gastroenterol 1997; 92: 2232–2236.
Boroń P, Bobrowska E, Kaczmarska A. Flisiak R, ?apiński W. Epidemiological and immunoserological evaluation of hepatitis B virus (HBV) infection in correlation with anti-delta and anti-HIV antibodies in alcoholics and drug addicts risk groups. In: Abstracts of the Regional Symposium of the World Psychiatric Association on Alcoholism and other Dependencies, Warsaw, November 1987; 21.
Boroń P, Boroń-Kaczmarska A, Bobrowska E, Kamińska H, ?apiński W. Epidemiological aspects of viral hepatitis B and delta-hepatitis in selected population from Bia?ystok District, Poland. Infection 1989; 17: 175–176.
Laskus T, Radkowski M, Lupa E, et al. Introduction of hepatitis delta virus into Polish drug community. Infection 1992; 20: 43–44.
Gaeta GB, Stroffolini T, Chiaramonte M, et al. Chronic hepatitis D: A vanishing Disease? An Italian multicenter study. Hepatology 2000; 32: 824–827.
Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis D virus genotypes in intravenous drug users in Taiwan: Decreasing prevalence and lack of correlation with hepatitis B virus genotypes. J Clin Microbiol 2002; 40: 3047–3049.
National Institute of Hygiene in Poland. Annual Reports 1993-2000.
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Chlabicz, S., Grzeszczuk, A., Łapiński, T. et al. Search for hepatitis delta virus (HDV) infection in hepatitis C patients in north-eastern Poland. Comparison with anti-HDV prevalence in chronic hepatitis B. Eur J Epidemiol 18, 559–561 (2003). https://doi.org/10.1023/A:1024694302251
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DOI: https://doi.org/10.1023/A:1024694302251