Skip to main content
SpringerLink
Log in

Differentiation of Bone Marrow Stromal Stem Cells into Cardiomyocyte-Like Cells in Different Mammalian Species

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We describe the possibility of obtaining cardiomyocyte-like cell cultures from rat, guinea pig, and human bone marrow stromal stem cells. The content of troponin I-positive cells attains 35-45% of the total number of cells in the cultures and persists at this level for up to 4 months under differentiation conditions. Spontaneous contractions of cardiomyocyte-like cells were observed after the formation of cell monolayer under differentiation conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. A. V. Revishchin, R. A. Poltavtseva, M. V. Marei, et al., Byull Eksp. Biol. Med., 132,No. 9, 285-289 (2001).

    Google Scholar 

  2. A. Ya. Fridenshtein, K. V. Petrakova, L. I. Kuralesova, and G. N. Frolova, Tsitologiya, 10,No. 5, 557-567 (1968).

    Google Scholar 

  3. A. Fridenshtein, Arch. Pathol., 44, 3-11 (1982).

    Google Scholar 

  4. S. Makino, K. Fukuda, S. Miyoshi, et al., J. Clin. Invest., 103,No. 5, 697-705 (1999).

    Google Scholar 

  5. M. Reyes, T. Lund, T. Lenvik, et al., Blood, 98,No. 9, 2615-2625 (2001).

    Google Scholar 

  6. B. Seshi, S. Kumar, and D. Sellers, Blood Cells Mol. Dis., 26,No. 3, 234-246 (2000).

    Google Scholar 

  7. S. Tomita, R. K. Li, R. D. Wiesel, et al., Circulation, 100,No. 19, Suppl., 247-256 (1999).

    Google Scholar 

  8. S. Wakitani, T. Saito, and A. Caplan, Muscle Nerve, 18, 1417-1426 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Transplantology and Artificial Organs, Ministry of Health of Russian Federation, Moscow

    V. I. Shumakov, N. A. Onishchenko, M. E. Krasheninnikov, V. A. Zaidenov, I. V. Potapov, L. V. Bashkina & A. V. Bersenev

Authors
  1. V. I. Shumakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. A. Onishchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. E. Krasheninnikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. A. Zaidenov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. V. Potapov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. V. Bashkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. V. Bersenev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. E. Krasheninnikov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shumakov, V.I., Onishchenko, N.A., Krasheninnikov, M.E. et al. Differentiation of Bone Marrow Stromal Stem Cells into Cardiomyocyte-Like Cells in Different Mammalian Species. Bulletin of Experimental Biology and Medicine 135, 393–396 (2003). https://doi.org/10.1023/A:1024681319084

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1024681319084

Search

Navigation