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Photodynamic Inhibition of Infection Caused by Drug-Resistant Variants of Herpes Simplex Virus Type I

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Abstract

Membranotropic amphiphilic chromophore merocyanine 540 sensitized photodynamic inhibition of drug-resistant and sensitive variants of type I herpes simplex virus in cultured Vero cell. Optimal conditions of photodamage to virus particles and infected cells were determined (merocyanine 540 concentration 1 μM, illumination dose 32.5-65.0 kJ/m2, exposure at early stages of infection). Infected cells actively bind the photosensitizer, which explains their selective photodamage.

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Authors and Affiliations

  1. State Institute of Epidemiology and Microbiology, Ministry of Health of Belarus Republic, Belarus

    Z. B. Kvacheva, N. A. Shukanova, V. I. Votyakov, E. S. Lobanok, A. V. Vorobei & S. N. Nikolaeva

  2. National Academy of Sciences of Belarus, Institute of Photobiology, Minsk

    Z. B. Kvacheva, N. A. Shukanova, V. I. Votyakov, E. S. Lobanok, A. V. Vorobei & S. N. Nikolaeva

Authors
  1. Z. B. Kvacheva
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  2. N. A. Shukanova
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  3. V. I. Votyakov
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  4. E. S. Lobanok
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  5. A. V. Vorobei
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  6. S. N. Nikolaeva
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Kvacheva, Z.B., Shukanova, N.A., Votyakov, V.I. et al. Photodynamic Inhibition of Infection Caused by Drug-Resistant Variants of Herpes Simplex Virus Type I. Bulletin of Experimental Biology and Medicine 135, 384–387 (2003). https://doi.org/10.1023/A:1024625201337

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  • DOI: https://doi.org/10.1023/A:1024625201337

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