Some Consequences of the RNA World Hypothesis

  • Leslie E. Orgel


It is now generally accepted that our familiar biological worldwas preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNAworld was the first biological world there is little that one canlearn from biochemistry about prebiotic chemistry, except that the formation and polymerization of nucleotides were once prebiotic processes. If the RNA world was not the first biological world, the above conclusion may not be justified, andone can speculate that the monomers of earlier genetic polymers might be recognizable as important biochemicals. This suggests that the construction of replicating polymers from simple, not necessarily standard, aminoacids should be explored.

non-biological peptides prebiotic chemistry replicating polymers the RNA world 


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  1. Baddiley J.: 1972, Teichoic Acid in Cell Walls and Membranes of Bacteria, Essays Biochem. 8, 35–77.Google Scholar
  2. Cairns-Smith, A. G. and Davies, C. J.: 1977, The Design of Novel Replicating Polymers, in R. Duncan and N. Weston-Smith (eds), Encyclopaedia of Ignorance, Pergamon Press, Oxford/New York.Google Scholar
  3. Chi, A. and Kemp, R. G.: 2000, The Primordial High Energy Compound: ATP or Inorganic Pyrophosphate?, J. Biol. Chem. 275, 35677–35679.Google Scholar
  4. Chyba, C. and Sagan, C.: 1992, Endogenous Production, Exogenous Delivery and Impact-Shock Synthesis of Organic Molecules: An Inventory for the Origin of Life, Nature 355, 125–132.Google Scholar
  5. Diederichsen, U.: 1996, Pairing Properties of Alanyl Peptide Nucleic Acids Containing an Amino Acid Backbone with Alternating Configuration, Angew. Chem. Int. Ed. Engl. 35, 445–448.Google Scholar
  6. Diederichsen, U. and Schmitt, H.W.: 1998, β-Homoalanyl PNAs: Synthesis and Indication of Higher Ordered Structures, Angew. Chem. Int. Ed 37, 302–305.Google Scholar
  7. Gesteland, R. F., Cech, T. R. and Atkins, J. F. (eds): 1999, in The RNA World, 2nd ed., Cold Spring Harbor Press.Google Scholar
  8. Huber, C. and Wächtershäuser, G.: 1997, Activated Acetic Acid by Carbon Fixation on (Fe,Ni)S Under Primordial Conditions, Science 276, 245–247.Google Scholar
  9. Joyce, G. F. and Orgel, L. E.: 1999, Prospects for Understanding the Origin of the RNA World, in The RNA World, 2nd ed., R. F. Gesteland, T. R. Cech and J. F. Atkins (eds), Cold Spring Harbor Press, Chapter 2, pp. 49–78.Google Scholar
  10. Kulaev, I. S. and Vagabov, V. M.: 1983, Polyphosphate Metabolism inMicro-organisms, Adv.Microb. Physiol. 24, 83–171.Google Scholar
  11. Kvenvolden, K., Lawless, J., Pering, K., Peterson, E., Flores, J., Ponnamperuma, C., Kaplan, I. R. and Moore, C.: 1970, Evidence for Extraterrestrial Amino Acids and Hydrocarbons in the Murchison Meteorite, Nature 228, 923–926.Google Scholar
  12. Miller, S. L.: 1953, A Production of Amino Acids Under Possible Primitive Earth Conditions, Science 117, 528–529.Google Scholar
  13. Nielsen, P. E.: 1998, Peptide Nucleic Acid. A Molecule with Two Identities, Acc. Chem. Res. 32, 624–630.Google Scholar
  14. Orgel, L. E.: 1968, Evolution of the Genetic Apparatus, J. Mol. Biol. 38, 381–393.Google Scholar
  15. Orgel, L. E. and Sulston, J. E.: 1971, Polynucleotide Replication and the Origin of Life, in Prebiotic and Chemical Evolution, A. P. Kimball and J. Oro (eds), Amsterdam, North Holland.Google Scholar
  16. Ragsdale, S.W. and Kumar, M.: 1996, Nickel-Containing Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase, Chem Rev. 96, 2515–2540.Google Scholar
  17. Schöning, K., Scholz, P., Guntha, S., Wu, X., Krishnamurthy, R. and Eschenmoser, A.: 2000, Chemical Etiology of Nucleic Acid Structure: The Alpha-Threofuranosyl-(3′→2′) Oligonucleotide System, Science 290, 1347–1351.Google Scholar
  18. Szostak, J. W., Bartel, D. P. and Luisi, P. L.: 2001, Synthesizing Life, Nature 409, 387–390.Google Scholar
  19. Wächtershäuser, G.: 1988, Pyrite Formation, The First Energy Source of Life: A Hypothesis, System. Appl. Microbiol. 10, 207–210.Google Scholar
  20. White, H. B.: 1976, Coenzymes as Fossils of an Earlier Metabolic State, J. Mol. Evol. 7, 101–104.Google Scholar
  21. Woese, C.: 1967, The Genetic Code, The Molecular Basis for Genetic Expression, Harper and Row, New York, pp. 179–195.Google Scholar
  22. Yoneth, A.: 2002, The Search and Its Outcome: High Resolution Structures of Ribosomal Particles from Mesophilic, Thermophilic, Halophilic Bacteria at Various Functional States, Ann. Rev. Biophys. Biomol. Struct. 31 257–273.Google Scholar

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Leslie E. Orgel
    • 1
  1. 1.The Salk Institute for Biological StudiesSan DiegoU.S.A

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