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Posthypoxic Disturbances in Glutamatergic Signal Transduction in Rat Brain Neurons: Correction Effect of Preconditioning

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Abstract

Severe 3-h hypobaric hypoxia was followed by impairment of Ca2+-mediated glutamatergic signal transduction in the posthypoxic period (no less than 72 h). This impairment manifested in changes in the calcium response to glutamate application in slices of rat brain cortex. Moderate hypoxic preconditioning prevented these disturbances developed over the first day after sever hypoxia.

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REFERENCES

  1. M. O. Samoilov, Brain and Adaptation: Molecular and Cellular Mechanisms [in Russian], St. Petersburg (1999).

  2. M. O. Samoilov, E. V. Lazarevich, A. A. Mokrushin, et al., Ros. Fiziol. Zh., 87,No. 6, 714-729 (2001).

    Google Scholar 

  3. M. O. Samoilov and A. A. Mokrushin, Dokl. Ros. Akad. Nauk, 354,No. 4, 565-567 (1997).

    Google Scholar 

  4. M. O. Samoilov and A. A. Mokrushin, Byull. Eksp. Biol. Med., 125,No. 5, 503-505 (1998).

    Google Scholar 

  5. M. O. Samoilov, D. G. Semenov, and A. A. Mokrushin, Vestn. Ros. Akad. Med. Nauk, No. 9, 32-39 (2000).

  6. D. G. Semenov, M. O. Samoilov, and E. V. Lazarevich, Byull. Eksp. Biol. Med., 31,No. 6, 621-624 (2001).

    Google Scholar 

  7. D. G. Semenov, E. I. Tyul'kova, and M. O. Samoilov, Fiziol. Zh., 81,No. 8, 51-55 (1995).

    Google Scholar 

  8. D. G. Semenov, E. I. Tyul'kova, M. O. Samoilov, and E. V. Lazarevich, Ros. Fiziol. Zh., 85,No. 1, 137-145 (1999).

    Google Scholar 

  9. E. I. Tyul'kova, D. G. Semenov, and M. O. Samoilov, Byull. Eksp. Biol. Med., 125,No. 3, 259-263 (1998).

    Google Scholar 

  10. D. W. Choi, J. Neurobiol., 23, 1261-1276 (1992).

    Google Scholar 

  11. D. Hatt, Naturwissenschafter, 86,No. 4, 177-186 (1999).

    Google Scholar 

  12. K. Ikemune, A. Mitani, S. Namba, et al., Neurosci. Lett., 275,No. 2, 125-128 (1999).

    Google Scholar 

  13. G. Tong, D. Shepherd, and C. E. Jahr, Science, 267,No. 5203, 1510-1512 (1995).

    Google Scholar 

  14. A. M. Wood and D. R. Bristow, J. Neurochem., 70,No. 2, 677-687 (1998).

    Google Scholar 

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Authors and Affiliations

  1. Russian Academy of Sciences, I. P. Pavlov Institute of Physiology, St. Petersburg

    O. L. Miller, D. G. Semenov & M. O. Samoilov

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  1. O. L. Miller
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  2. D. G. Semenov
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  3. M. O. Samoilov
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Miller, O.L., Semenov, D.G. & Samoilov, M.O. Posthypoxic Disturbances in Glutamatergic Signal Transduction in Rat Brain Neurons: Correction Effect of Preconditioning. Bulletin of Experimental Biology and Medicine 135, 340–342 (2003). https://doi.org/10.1023/A:1024600528654

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