Skip to main content
Log in

Metabolism of L-Arginine (A Review)

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

REFERENCES

  1. S. Moncada, R. M. S. Palmer, and E. A. Higgs, Pharmacol. Rev., 43, 109–141 (1991).

    Google Scholar 

  2. M. A. Marletta, J. Med. Chem., 37, 1899–1921 (1994).

    Google Scholar 

  3. O. W. Griffith and D. J. Stuehr, Annu. Rev. Physiol., 57, 707–736 (1995).

    Google Scholar 

  4. V. G. Granik, S. Yu. Ryabova, and N. B. Grigor'ev, Usp. Khim., 66(8), 792–807 (1997).

    Google Scholar 

  5. A. F. Vanin, Biokhimiya, 63(7), 924–938 (1998).

    Google Scholar 

  6. I. S. Severina, Biokhimiya, 63(7), 939–947 (1998).

    Google Scholar 

  7. E. B. Men'shikova, N. K. Zenkov, and V. P. Reutov, Biokhimiya, 65(4), 485–503 (2000).

    Google Scholar 

  8. Nitric Oxide. Basic Research and Clinical Application, R. J. Gryglewsky, and P. Minuz (eds.), IOS Press, Amsterdam, Berlin, Oxford, Tokyo, Washington, DC (2001).

    Google Scholar 

  9. D. Voet and J. G. Voet, Biochemistry, 2th Ed., John Wiley and Sons Inc., New York, Chichester, Brisbane, Toronto, Singapore (1995), p. 1290.

    Google Scholar 

  10. F. Murad, Neurotransmissions, X(2), 1–4 (1994).

    Google Scholar 

  11. H. Al-Sa'Doni and A. Ferro, Clin. Sci., 98, 507–520 (2000).

    Google Scholar 

  12. M. Feelish, J. Cardiovas. Pharm., 17(Suppl. 3), 25–33 (1991).

    Google Scholar 

  13. V. P. Reutov, E. G. Sorokina, V. E. Okhotin, and N. S. Kositsyn, Cyclic Transformations of Nitrogen Oxide in Mammals [in Russian], Nauka, Moscow (1998).

    Google Scholar 

  14. G. Wu and S. M. Morris, Biochem. J., 336, 1–17 (1998).

    Google Scholar 

  15. G. Wu, P. K. Devis, N. E. Flynn, et al., J. Nutr., 127, 2342–2349 (1997).

    Google Scholar 

  16. G. Wu, J. Nutr., 128, 1249–1252 (1998).

    Google Scholar 

  17. H. K. Berthold, R. J. Reeds, and P. D. Klein, Clin. Exp. Metab., 44, 466–479 (1995).

    Google Scholar 

  18. A. Leninger, Principles of Biochemistry, Worth, New York (1982).

    Google Scholar 

  19. V. G. Granik and N. B. Grigor'ev, Izv. Ross. Akad. Nauk, Ser. Khim., No. 8, 1268–1313 (2002).

  20. V. G. Granik and N. B. Grigor'ev, Izv. Ross. Akad. Nauk, Ser. Khim., No. 11, 1819–1841 (2002).

  21. P. G. Wang, M. Xian, X. Tang, et al., Chem. Rev., 102, 1091–1139 (2002).

    Google Scholar 

  22. S. M. Morris, D. K. Nakayama, A. K. Nussler, et al., The Biology of Nitric Oxide, Vol. 4, Enzymology, Biology and Immunology, S. Moncada, M. Feelish, R. Busse, E. A. Higgs (eds.), Portland Press, London (1994), pp. 301–303.

    Google Scholar 

  23. M. Hecker, W. C. Sessa, H. J. Harris, et al., Proc. Natl. Sci. USA, 87, 8612–8616 (1990).

    Google Scholar 

  24. S. M. Morris and T. R. Billiar, Am. J. Physiol., 266, E829–E839 (1994).

    Google Scholar 

  25. L. Xie and S. S. Gross, J. Biol. Chem., 272, 16624–16650 (1997).

    Google Scholar 

  26. G. Li, S. Regunathan, J. Barrow, et al., Science, 263, 966–969 (1994).

    Google Scholar 

  27. M. D. Mashkovskii, Drugs [in Russian], Torsing, Kharkov (1997).

    Google Scholar 

  28. M. D. Mashkovskii, Drugs of the XXI Century [in Russian], Novaya Volna, Moscow (1998).

    Google Scholar 

  29. J. Satriano, S. Matsufuji, Y. Marakami, et al., J. Biol. Chem., 273, 15313–15316 (1998).

    Google Scholar 

  30. R. C. Blantz, J. Satriano, F. Gabbai, and C. J. Kelly, Acta Physiol. Scand., 168, 21–27 (2000).

    Google Scholar 

  31. A. Galea, S. Regunathan, V. Eliopoulos, et al., Biochem. J., 316, 247–249 (1996).

    Google Scholar 

  32. M. J. Lortie, W. F. Novotny, and O. W. Peterson, J. Clin. Invest., 97, 413–420 (1996).

    Google Scholar 

  33. D. Schwartz, O. W. Peterson, M. Mendonca, et al., Am. J. Physiol., 272, F597–F601 (1997).

    Google Scholar 

  34. D. J. Stuer, Annu. Rev. Pharmacol. Toxicol., 37, 339–359 (1997).

    Google Scholar 

  35. G. M. Boga, R. Singh, S. Pervin, et al., Am. J. Physiol., 271, 1988–1998 (1996).

    Google Scholar 

  36. G. Wu and C. J. Meininger, Am. J. Physiol., 269, 1312–1318 (1995).

    Google Scholar 

  37. V. G. Granik, Drugs: Pharmacological, Biochemical, and Chemical Aspects, [in Russian], Vuz. Kniga, Moscow (2001).

    Google Scholar 

  38. M. A. Creager, S. M. Gallagher, X. J. Giverd, et al., J. Clin. Invest., 90, 1248–1255 (1992).

    Google Scholar 

  39. J. L. Dubois, R. Zelinsky, F. Roudot, et al., Am. J. Cardiol., 70, 1269–1276 (1992).

    Google Scholar 

  40. H. G. Williams-Ashman and Z. N. Canellakis, Perspect. Biol. Med., 22, 421–453 (1979).

    Google Scholar 

  41. A. E. Pegg and P. P. McCann, Am. J. Physiol., 243, 212–221 (1982).

    Google Scholar 

  42. C. W. Tabor and H. Tabor, Annu. Rev. Biochem., 53, 749–790 (1984).

    Google Scholar 

  43. A. E. Pegg, Biochem. J., 234, 249–262 (1986).

    Google Scholar 

  44. C. W. Porter and J. R. Sufrin, Anticancer. Res., 6, 525–542 (1986).

    Google Scholar 

  45. J. Janne, E. Hollta, A. Kallio, et al., Spec. Top. Endocrinol. Metab., 5, 227–293 (1983).

    Google Scholar 

  46. P. P. McCann and A. E. Pegg, A Sjoerdsma, Biological Significance and Basis for New Therapies, Orlando, FL: Academic Press (1987), pp. 1–371.

    Google Scholar 

  47. A. E. Pegg, Cancer Res., 48, 759–774 (1988).

    Google Scholar 

  48. A. E. Pegg, R. S. Wechter, R. S. Clark, et al., Biochemistry, 25, 379–384 (1986).

    Google Scholar 

  49. A Sjoerdsma and P. J. Schechter, Clin. Pharmacol. Ther., 35, 287–300 (1984).

    Google Scholar 

  50. A. E. Pegg, K.-C. Tang, and J. K. Coward, Biochemistry, 21, 5082–5086 (1982).

    Google Scholar 

  51. A. E. Pegg, D. B. Jones, and J. A. Secrist, Biochemistry, 21, 5097–5102 (1982).

    Google Scholar 

  52. L. Alhonen-Hongisto, P. Seppanen, and J. Janne, Biochem. J., 192, 941–945 (1982).

    Google Scholar 

  53. A. Kallio, J. Janne, Biochem. J., 212, 895–901 (1983).

    Google Scholar 

  54. A. Kallio, P. Nikula, and J. Janne, Biochem. J, 218, 641–644 (1984).

    Google Scholar 

  55. V. A. Levin, M. C. Chamberlain, M. D. Prados, et al., Cancer Treat. Rep., 71, 459–465 (1987).

    Google Scholar 

  56. R. Scleiffer, B. Duranton, F. Gosse, et al., Nitric Oxide: Biol., Chem., 4, 583–589 (2000).

    Google Scholar 

  57. N. Seiler, C. L. Atanasov, and F. Raul, Int. J. Oncol., 13, 993–1006 (1998).

    Google Scholar 

  58. F. Blachier, A. Mignon, and O. Soubrane, Nitric Oxide: Biol., Chem., 1, 268–272 (1997).

    Google Scholar 

  59. J. Satriano, S. Ishizuka, D. C. Archer, et al., Am. J. Physiol., 276, C 892–899 (1999).

    Google Scholar 

  60. A. Al'bert, Specific Toxicity [Russian Translation], Meditsina, Moscow (1989), Vols. 1 and 2.

    Google Scholar 

  61. G. I. Zhungietu and V. G. Granik, Basic Principles of Drug Design [in Russian], Moldova State University, Kishinev (2000).

    Google Scholar 

  62. V. G. Granik, Principles of Medicinal Chemistry [in Russian], Vuz. Kniga, Moscow (2001).

    Google Scholar 

  63. J. G. Cannon, Pharmacology for Chemists, Oxford University Press, N. Y., Oxford (1999).

    Google Scholar 

  64. S. W. Porter, R. J. Bergeron, and N. J. Stolowich, Cancer Res., 42, 4072–4078 (1982).

    Google Scholar 

  65. S. W. Porter, P. F. Cavanaugh, N. J. Stolowich, et al., Cancer Res., 45, 2050–2056 (1985).

    Google Scholar 

  66. W. D. W. Heston, C.-R. Yang, L. Pliner, et al., Cancer Res., 47, 3627–3631 (1987).

    Google Scholar 

  67. D. A. Wooley, A Study of Antimetabolites, New York (1952).

  68. R. A. Cosero, R. J. Bergeron, and S. W. Porter, J. Cell. Physiol., 121, 476–482 (1984).

    Google Scholar 

  69. K. A. Govern, P. S. Clark, and A. E. Pegg, J. Cell. Physiol., 127, 311–316 (1986).

    Google Scholar 

  70. S. W. Porter, B. Ganis, T. Vinson, et al., Cancer Res., 46, 6279–6285 (1986).

    Google Scholar 

  71. S. W. Porter, J. McManis, R. A. Casero, et al., Cancer Res., 47, 2821–2827 (1987).

    Google Scholar 

  72. B. G. Erwin and A. E. Pegg, Biochem. J, 238, 581–587 (1986).

    Google Scholar 

  73. R. Casero, B. Go, H. W. Theiss, et al., Cancer Res., 47, 3964–3967 (1987).

    Google Scholar 

  74. L. J. Marton, Pharmacol. Ther., 32, 183–190 (1987).

    Google Scholar 

  75. I. Sano, D. F. Deen, S. M. Oredsson, et al., Cancer Res., 44, 577–583 (1984).

    Google Scholar 

  76. L. J. Marton, V. A. Levin, S. J. Hervatin, et al., Cancer Res., 41, 4426–4433 (1981).

    Google Scholar 

  77. L. J. Marton, in: “Polyamine in Clinical Disorder” (D. F. Tierney, Moderator), West. J. Med., 142, 63–69 (1985).

    Google Scholar 

  78. J. Seidenfeld and R. K. A. Komar, Cancer Res., 45, 2132–2137 (1985).

    Google Scholar 

  79. A. V. Danilov, O. B. Romanova, I. K. Sorokina, et al., Vopr. Biol. Med. Farm. Khim., No. 2, 50–55 (2001).

  80. J. M. Ducore and L. McNamara, Cancer Res., 46, 1068–1077 (1986).

    Google Scholar 

  81. M. A. Moore, H. Tsuda, T. Ogiso, et al., Cancer Lett., 25, 145–149 (1982).

    Google Scholar 

  82. T. Nakadate, E. Aizu, S. Yamamoto, et al., Jpn. J. Pharmacol., 37, 253–260 (1985).

    Google Scholar 

  83. R. A. Malt, A. N. Kingsnorth, G. M. Lamuraglia, et al., Adv. Enzym. Regul., 24, 93–97 (1985).

    Google Scholar 

  84. Y. Homma, S. Ozono, I. Numata, et al., Carcinogenesis (Lond.), 6, 159–166 (1985).

    Google Scholar 

  85. H. J. Thompson and A. M. Ronan, Carcinogenesis (Lond.), 7, 2003–2006 (1986).

    Google Scholar 

  86. N. D. Nigro, A. W. Bull, and M. E. Boyd, J. Natl. Cancer Inst., 77, 1309–1313 (1986).

    Google Scholar 

  87. G. D. Luk and S. B. Baylin, N. Engl. J. Med., 311, 80–87 (1984).

    Google Scholar 

  88. R. J. Moorehead, M. Hoper, and S. T. D. McKelvay, Br. J. Surg., 74, 364–368 (1987).

    Google Scholar 

  89. H. G. Williams-Ashman, J. Seidenfeld, and P. Galetti, Biochem. Pharmacol., 35, 1217–1224 (1982).

    Google Scholar 

  90. F. Schlenk, Adv. Enzymol., 54, 195–201 (1983).

    Google Scholar 

  91. H. Yamanaka, M. Kubota, D. A. Carson, Cancer Res., 47, 1771–1774 (1987).

    Google Scholar 

  92. P. S. Mamont, M.-C. Duchesne, J. Grove, et al., Exp. Cell. Res., 115, 387–392 (1978).

    Google Scholar 

  93. E. E. Medrano, O. R. Burrone, M. M. Ferrer, et al., FEBS Lett., 206, 106–108 (1986).

    Google Scholar 

  94. M. Carteni-Farina, G. Cacciapuoti, M. Porcelli, et al., Biochim. Biophys. Acta, 805, 158–167 (1984).

    Google Scholar 

  95. M. C. Pancaskie and D. D. Lakin, Biochem. Pharmacol., 36, 2063–2074 (1987).

    Google Scholar 

  96. T. M. Savarese, L. Y. Ghoda, and R. E. Park, In: Y.-C. Cheng, B. Goz, M. Mincoff (eds.), Development of Target Oriented Anticancer Drugs, Raven Press, New York (1983), pp. 129–142.

    Google Scholar 

  97. J. Loscalzo, Circulation, 101, 2126–2129 (2000).

    Google Scholar 

  98. N. Gocke, J. F. Keaney, B. Frei, et al., Circulation, 99, 3234–3239 (1999).

    Google Scholar 

  99. J. V. Mombouli, Drugs, 54(suppl. 5), 12–22 (1997).

    Google Scholar 

  100. M. A. Creager, S. M. Gallagher, X. J. Cirerd, et al., J. Clin. Invest., 90, 1248–1253 (1992).

    Google Scholar 

  101. J. L. Dubois-Rande, R. Zelinsky, F. Roudot, et al., Am. J. Cardiol., 70, 1269–1275 (1992).

    Google Scholar 

  102. M. T. Jay, S. Chirico, R. C. Siow, et al., Exp. Physiol., 82, 349–356 (1997).

    Google Scholar 

  103. K. Kikuta, T. Sawamura, S. Miwa, et al., Circ. Res., 83, 1088–1092 (1998).

    Google Scholar 

  104. H. Miuazaki, H. Matsuoka, J. P. Cooke, et al., Circulation, 99, 1141–1146 (1999).

    Google Scholar 

  105. D. Giuliano, R. Marfella, G. Verazzo, et al., J. Clin. Invest., 99, 433–438 (1997).

    Google Scholar 

  106. C. M. Giraldelo, A. Zappellini, N. N. Muscara, et al., Eur. J. Pharmacol., 257, 87–93 (1994).

    Google Scholar 

  107. J. P. F. Chin-Dusting, C. T. Alexander, P. J. Arnold, et al., J. Cardiovasc. Pharmacol., 28, 158–164 (1996).

    Google Scholar 

  108. A. Blum, L. Hathaway, L. Mincemoyer, et al., Circulation, 101, 2160–2166 (2000).

    Google Scholar 

  109. E. Stroes, J. Kastelein, F. Cosentino, et al., J. Clin. Invest., 99, 41–44 (1997).

    Google Scholar 

  110. G. M. Pieper, Hypertension, 31, 1047–1060 (1998).

    Google Scholar 

  111. V. Grill, O. Bjorkman, M. Gutniak, et al., Metabolism, 41, 28–34 (1992).

    Google Scholar 

  112. L. Hagenfeldt, G. Dahlquist, and B. Persson, Acta Pediatr. Scand., 794, 278–283 (1989).

    Google Scholar 

  113. T. C. Wascher, K. Posch, S. Wallner, et al., Biochem. Biophys. Res. Commun., 234, 35–38 (1997).

    Google Scholar 

  114. E. Brand and M. Sandberg, Organic Synth., Coll. Vol. II (1943), pp. 49–55.

    Google Scholar 

  115. K. Odo, J. Chem. Soc. Jpn., Pure Chem. Sect., 74, 774–778 (1953).

    Google Scholar 

  116. P. A. S. Smith, Organic Synth., Coll. Vol. IV (1963), pp. 819–824.

    Google Scholar 

  117. J. von Brown and W. Pinkernelle, Chem. Ber., 70, 1230–1237 (1937).

    Google Scholar 

  118. M. Israel, J. S. Rosenfield, and E. J. Modest, J. Med. Chem., 7(6), 710–718 (1964).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Granik, V.G. Metabolism of L-Arginine (A Review). Pharmaceutical Chemistry Journal 37, 111–127 (2003). https://doi.org/10.1023/A:1024578429137

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1024578429137

Keywords

Navigation