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Penicillium aurantiogriseum Dierckx 1901: Producer of Diketopiperazine Alkaloids (Roquefortine and 3,12-Dihydroroquefortine), Isolated from Permafrost

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Abstract

Secondary metabolites of three strains of Penicillium aurantiogriseumisolated from permafrost sediments were identified. It was found that these fungi synthesized the diketopiperazine alkaloids roquefortine and 3,12-dihydroroquefortine. The strain VKM FW-766 synthesized alkaloids in the course of certain growth-related processes. When the strain was grown on a mineral medium, the time courses of the roquefortine and 3,12-dihydroroquefortine concentrations were characterized by biphasic curves.

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Authors and Affiliations

  1. Russian Academy of Sciences, Skryabin Institute of Biochemistry and Physiology of Microorganisms, pr. Nauki 5, Pushchino, Moscow oblast, 142290, Russia

    A. G. Kozlovsky, V. P. Zhelifonova, V. M. Adanin, T. V. Antipova, S. M. Ozerskaya & N. E. Ivanushkina

  2. Hans-Knoll Institute of Natural Product Research, Jena, D-07745, Germany

    U. Grafe

Authors
  1. A. G. Kozlovsky
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  2. V. P. Zhelifonova
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  3. V. M. Adanin
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  4. T. V. Antipova
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  5. S. M. Ozerskaya
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  6. N. E. Ivanushkina
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  7. U. Grafe
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Kozlovsky, A.G., Zhelifonova, V.P., Adanin, V.M. et al. Penicillium aurantiogriseum Dierckx 1901: Producer of Diketopiperazine Alkaloids (Roquefortine and 3,12-Dihydroroquefortine), Isolated from Permafrost. Applied Biochemistry and Microbiology 39, 393–397 (2003). https://doi.org/10.1023/A:1024572602458

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  • DOI: https://doi.org/10.1023/A:1024572602458

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