Lycopene therapy in idiopathic male infertility – a preliminary report

Abstract

Excessive generation of reactive oxygen species(ROS) containing free oxygen radicals has beenidentified as one of the causes of maleinfertility. Lycopene is a component of humanredox defence mechanism against free radicals.It is found in high concentrations in thetestes and seminal plasma and decreased levelshave been demonstrated in men suffering frominfertility. We evaluated the effect of orallycopene therapy in men with idiopathicinfertility. Beginning March 2000, thirty menwith idiopathic non-obstructiveoligo/astheno/teratozoospermia were enrolledfor the trial. All patients were administered2000 mcg of Lycopene, twice a day for threemonths. Semen analysis was performed at threemonths and sperm concentration, motility andmorphology were evaluated. All patientscompleted the trial without any complications.Twenty patients (66%) showed an improvement insperm concentration, sixteen (53%) hadimproved motility and fourteen (46%) showedimprovement in sperm morphology. In casesshowing an improvement, the median change inconcentration was 22 million/ml, motility 25%and morphology 10%. The improvement inconcentration and motility were statisticallysignificant. Baseline sperm concentration lessthan 5 million/ml was associated with nosignificant improvement. Higher baselineconcentrations were associated with significantimprovement and resulted in six pregnancies in26 patients (23%). Oral Lycopene therapy seemsto have a role in the management of idiopathicmale infertility. Maximum improvement seems tooccur in the sperm concentration (66% cases).Patients without severe oligospermia (spermdensity >5 million/ml) may be given a trialof therapy with lycopene. However, largerrandomised controlled trials are essentialbefore definitive therapeutic guidelines can bemade.

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References

  1. 1.

    Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil 1987; 81: 459–469.

    Google Scholar 

  2. 2.

    Iwasaki A, Gagnon C. Formation of reactive oxygen species in spermatozoan of infertile patients. Fertil Steril 1992; 57: 409–416.

    Google Scholar 

  3. 3.

    Sigman M, Howards SS. Male infertility. In: Walsh PC, Retik AB, Vaughan Jr ED, Wein AJ, eds. Campbell's Urology (7th edn.). Philadelphia: WB Saunders Company, 1998: 1287–1320.

    Google Scholar 

  4. 4.

    Marmar JL, Kim Y. Subinguinal microsurgical variciocelectomy: a technical critique and statistical analysis of semen and pregnancy data.

  5. 5.

    Greenhall E, Vessey M. The prevalence of subfertility: a review of the current confusion and a report of two new studies. Fertil Steril 1990; 54: 978–983.

    Google Scholar 

  6. 6.

    Mosher WD, Pratt WF. Fecundity and infertility in the United States: incidence and trends. Fertil Steril 1991; 56: 192–193.

    Google Scholar 

  7. 7.

    Smith KD, Rodriguez-Rigau LJ, Steinberger E. Relation between indices of semen analysis and pregnancy rate in infertile couples. Fertil Steril 1977; 28: 1314–1319.

    Google Scholar 

  8. 8.

    WHO. Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction (3rd edn.). Cambridge: Cambridge University Press, 1992.

    Google Scholar 

  9. 9.

    Hull M, Glazener C, Kelly N et al. Population study of causes, treatment and outcome of infertility. Br Med J 1985; 291: 1693–1697.

    Google Scholar 

  10. 10.

    Aitken RJ, Irvine DS, Wu FC. Prospective analysis of sperm oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol 1991; 164: 542–551.

    Google Scholar 

  11. 11.

    Lewis SE, Boyle PM, McKinney KA et al. Total antioxidant capacity of seminal plasma is different in fertile and infertile men. Fertil Steril 1994; 64: 411–419.

    Google Scholar 

  12. 12.

    Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology 1996; 48: 835–850.

    Google Scholar 

  13. 13.

    Aitken RJ, Clarkson JS, Hargreave TB et al. Analysis of relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl 1989; 10: 214–220.

    Google Scholar 

  14. 14.

    Armstrong JS, Rajasekaran M, Chamulitrat Wet al. Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radic Biol Med 1999; 26: 869–880.

    Google Scholar 

  15. 15.

    Sikka SC. Oxidative stress and role of antioxidants in normal and abnormal sperm function. Front Biosci 1996: 78–86.

  16. 16.

    Kessopoulou E, Powers HJ, Sharma KK et al. A double blind randomised placebo crossover controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril 1995; 64: 825–831

    Google Scholar 

  17. 17.

    Thiele JL, Freisleben HJ, Fuchs J, Ochsendorf FR. Ascorbic acid and urate in human seminal plasma: determination and interrelationships with chemiluminiscence in washed semen. Hum Reprod 1993; 10: 110–115.

    Google Scholar 

  18. 18.

    Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989; 274: 532–538.

    Google Scholar 

  19. 19.

    Klebanov GI, Kapitanov AB, Teselkin YoU et al. the antioxidant properties of Lycopene. Membr Cell Biol 1998; 12: 287–300.

    Google Scholar 

  20. 20.

    Palan P, Naz R. Changes in various antioxidant levels in human seminal plasma related to immunoinfertility. Arch Androl 1996; 36: 139–143

    Google Scholar 

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Correspondence to Narmada P. Gupta.

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Gupta, N.P., Kumar, R. Lycopene therapy in idiopathic male infertility – a preliminary report. Int Urol Nephrol 34, 369–372 (2002). https://doi.org/10.1023/A:1024483520560

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  • Andrology
  • Antioxidants
  • Carotenoids
  • Oxidative stress
  • Reactive oxygen species (ROS)