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Crystallization of chiral compounds. 2. Propranolol: free base and hydrochloride

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Abstract

The data from IR spectroscopy, differential scanning calorimetry, and X-ray diffraction analysis are compared for crystalline specimens of homochiral and racemic propranolol and its hydrochloride. The stabilities of the racemates were quantitatively characterized and the factors responsible for the order of their stability are revealed.

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088, Kazan, Russian Federation

    A. A. Bredikhin, D. V. Savel"ev, Z. A. Bredikhina, A. T. Gubaidullin & I. A. Litvinov

Authors
  1. A. A. Bredikhin
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  2. D. V. Savel"ev
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  3. Z. A. Bredikhina
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  4. A. T. Gubaidullin
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  5. I. A. Litvinov
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Bredikhin, A.A., Savel"ev, D.V., Bredikhina, Z.A. et al. Crystallization of chiral compounds. 2. Propranolol: free base and hydrochloride. Russian Chemical Bulletin 52, 853–861 (2003). https://doi.org/10.1023/A:1024435906421

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  • DOI: https://doi.org/10.1023/A:1024435906421

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